9 documents found, page 1 of 1

Analysis of potential risk factors for multidrug-resistance at a burn unit

Background: Infections by multidrug-resistant (MDR) microorganisms are associated with increased morbidity and mortality in burn patients. This study aimed to analyze the evolution of MDR bacteria over a five-year period at Coimbra Burns Unit (CBU) in Portugal, seeking to assess the possible associations of specific bacteria with presumed risk factors. Methods: The data obtained consisted of identified bacteria...

Bacterial multidrug resistance description in Coimbra Burns Unit, 2016-2020

PCT kinetics in the first week postburn for sepsis diagnosis and death prognosi...

Despite continuous advances in burn care, sepsis is still the main cause of death in burn patients. Procalcitonin (PCT) has been reported as an accurate sepsis biomarker and also as a fair predictor of death. The aim of this study was to assess PCT kinetics in the first week postburn regarding sepsis diagnosis and death prognosis. Sample included 142 patients with ≥15% TBSA, admitted from January 2011 to Decemb...

Bacterial multidrug resistance description in Coimbra Burns Unit, 2016-2020

No abstract available.

Procalcitonin in burn patients: diagnosis of sepsis and prognosis of death in t...

Updates on Coagulation: Non-Vitamin K Antagonist Oral Anticoagulants (NOACs)

Non-vitamin K antagonist oral anticoagulants (NOACs) have appeared as a therapeutic alternative to vitamin K antagonists (VKAs). NOACs introduction has changed oral anticoagulation. They are clinically indicated for the prevention of thromboembolic phenomena in patients with non-valvular atrial fibrillation and for the primary and secondary prevention of venous thromboembolism, specifically deep vein thrombosis...

Evaluation of procalcitonin accuracy for the distinction between gram-negative ...

Sepsis is the main cause of death in burns. Early institution of antimicrobial therapy is crucial to optimize outcomes but superfluous therapy increases adverse events, microbial resistance, and costs. Blood cultures are the gold standard for diagnosis but can take 48 to 72 hours. Biomarkers are used to help sepsis diagnosis and distinction between Gram-negative and Gram-positive bacterial cause. The aim of thi...

Checking procalcitonin suitability for prognosis and antimicrobial therapy moni...

Due to greater infection susceptibility, sepsis is the main cause of death in burn patients. Quick diagnosis and patient stratification, early and appropriated antimicrobial therapy, and focus control are crucial for patients' survival. On the other hand, superfluous extension of therapy is associated with adverse events and arousal of microbial resistance. The use of biomarkers, necessarily coupled with close ...

Toxic Epidermal Necrolysis: The Experience of Coimbra’s Burn Unit

Introduction: Toxic Epidermal Necrolysis is a drug-induced life-threatening systemic disease, characterized by extensive dermoepidermal detachment and mucositis. At least 95% of cases are believed to be drug-induced. SCORTEN is a scoring system used to stratify severity and predict mortality. Treatment demands immediate withdrawal of the causative drug and early transfer to a burn centre for specific and intens...