3 documents found, page 1 of 1
Bone Histomorphometry Revisited
Vidal, B; Pinto, A; Galvão, MJ; Santos, AR; Rodrigues, A; Cascão, R; Abdulghani, S; Caetano-Lopes, J; Ferreira, A; Fonseca, JE; Canhão, HBone histomorphometry is defined as a quantitative evaluation of bone micro architecture, remodelling and metabolism. Bone metabolic assessment is based on a dynamic process, which provides data on bone matrix formation rate by incorporating a tetracycline compound. In the static evaluation, samples are stained and a semi-automatic technique is applied in order to obtain bone microarchitectural parameters such ...
Smoking is a predictor of worse trabecular mechanical performance in hip fragil...
Rodrigues, AM; Caetano-Lopes, J; Vale, AC; Aleixo, I; Pena, AS; Faustino, A; Sepriano, A; Polido-Pereira, J; Vieira-Sousa, E; Lucas, R; Romeu, JCClinical risk factors (CRFs) are established predictors of fracture events. However, the influence of individual CRFs on trabecular mechanical fragility is still a subject of debate. In this study, we aimed to assess differences, adjusted for CRFs, between bone macrostructural parameters measured in ex-vivo specimens from hip fragility fracture patients and osteoarthritis patients, and to determine whether indi...
Upregulation of inflammatory genes and downregulation of sclerostin gene expres...
Caetano-Lopes, J; Lopes, A; Rodrigues, A; Fernandes, D; Perpétuo, IP; Monjardino, T; Lucas, R; Monteiro, J; Konttinen, YT; Canhão, H; Fonseca, JEBackground: Fracture healing is orchestrated by a specific set of events that culminates in the repair of bone and reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients. Methodology/Principal Findings: Fifty-six patients submitte...