1 document found, page 1 of 1
Sort by
Issue Date
Mulberry leaf lipid nanoparticles: a naturally targeted CRISPR/Cas9 oral delive...
Ma, Lingli; Ma, Ya; Gao, Qiang; Liu, Shengsheng; Zhu, Zhenhua; Shi, Xiaoxiao; Dai, Fangyin; Reis, R. L.; Kundu, Subhas C; Cai, Kaiyong; Xiao, BoOral treatment of colon diseases with the CRISPR/Cas9 system has been hampered by the lack of a safe and efficient delivery platform. Overexpressed CD98 plays a crucial role in the progression of ulcerative colitis (UC) and colitis-associated colorectal cancer (CAC). In this study, lipid nanoparticles (LNPs) derived from mulberry leaves are functionalized with Pluronic copolymers and optimized to deliver the CR...
Date: 2024
|
Origin: RepositóriUM - Universidade do Minho