1 document found, page 1 of 1
Sort by
Issue Date
A SOX2 reporter system identifies gastric cancer stem-like cells sensitive to m...
Pádua, D; Barros, R; Amaral, AL; Mesquita, P; Freire, AF; Sousa, M; Maia, AF; Caiado, I; Fernandes, H; Pombinho, AR; Pereira, CF; Almeida, RGastric cancer remains a serious health burden with few therapeutic options. Therefore, the recognition of cancer stem cells (CSCs) as seeds of the tumorigenic process makes them a prime therapeutic target. Knowing that the transcription factors SOX2 and OCT4 promote stemness, our approach was to isolate stem-like cells in human gastric cancer cell lines using a traceable reporter system based on SOX2/OCT4 acti...
Date: 2020
|
Origin: Repositório Aberto da Universidade do Porto