6 documents found, page 1 of 1
Lipid-based nanostructures as a strategy to enhance curcumin bioaccessibility: ...
Gonçalves, Raquel Filipa Silva; Martins, Joana Teresa Rodrigues; Abrunhosa, Luís; Baixinho, João; Matias, Ana A.; Vicente, A. A.; Pinheiro, A. C.The aim of this study was to evaluate the behavior of different lipid-based nanostructures during in vitro digestion, in particular on curcumins bioaccessibility, and to access their potential toxicity. Solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC) and nanoemulsions (NE) were submitted to harmonized static in vitro digestion and their cytotoxicity and cellular transport were evaluated usi...
Therapeutic role of deep eutectic solvents based on menthol and saturated fatty...
Silva, Joana M.; Pereira, Carolina Jesus Vieira; Mano, Francisca; Silva, Eduardo; Castro, Vânia Isabel Baptista; Sá-Nogueira, Isabel; Reis, R. L.The breakthroughs achieved in green solvents promote the emergence of therapeutic deep eutectic solvents (THEDES), which possess intriguing possible applications in the biomedical field. Herein, the main aim was to unravel the biomedical potential of hydrophobic THEDES based in menthol and saturated fatty acids with different chain lengths (e.g., stearic acid (SA), myristic acid (MA), and lauric acid (LA)). Our...
Solubility and Permeability Enhancement of active compounds: Therapeutic Deep E...
Duarte, Ana Rita C.; Barreiros, Susana; Matias, Ana A.; Reis, R. L.; Paiva, AlexandreTherapeutic deep eutectic systems (THEDES) are here proposed as a new class of pharmaceutical active ingredient (API) whose distinctive characteristic is the fact that they are liquid at room temperature. Eutectic systems have been described in the pharmaceutical sciences as an alternative formulation able to enhance bioavailability of the API. THEDES are constituted by one active agent and a coformer or two ac...
Cholinium-based ionic liquids with pharmaceutically active anions
Araujo, Joao M. M.; Florindo, Catarina; Pereiro, Ana B.; Vieira, Nicole S. M.; Matias, Ana A.; Duarte, Catarina M. M.; Rebelo, Luis P. N.Novel ionic liquids (ILs) containing cholinium as a benign cation combined with anions based on five active pharmaceutical ingredients (APIs), namely, nalidixic acid, niflumic acid, 4-amino-salicylic acid, pyrazinoic acid and picolinic acid, were prepared via a simple and sustainable two-step anion exchange reaction. The solubility of the prepared pharmaceutically active ILs (API-ILs) in both water and simulate...
Supercritical fluid extraction of carotenoids and chlorophylls a, b and c, from...
Guedes, A. Catarina; Gião, Maria S.; Matias, Ana A.; Nunes, Ana V. M.; Pintado, Manuela E.; Duarte, Catarina M. M.; Malcata, F. XavierFaster and more selective extraction methods are urged to recover food-grade pigments and antioxidants from microalgae - which do not resort to food-incompatible and environment-unfriendly solvents. Hence, this study ascertained the influence of pressure, temperature, CO2 flow rate and a polar co-solvent upon the yields of carotenoids and chlorophylls in supercritical fluid extraction of Scenedesmus obliquus bi...
Avaliação da nanotoxicidade de nanopartículas lipidicas aplicadas na formulação...
Nunes, Sara; Duarte, Catarina M. M.; Matias, Ana A.; Rivera, Melissa C.; Bourbon, Ana I.; Cerqueira, Miguel Ângelo Parente Ribeiro; Vicente, A. A.[Excerto] Tem sido crescente a evidência de que nanopartículas podem induzir toxicidade celular relevante com forte impacto na saúde humana. Esta toxicidade pode ser expressa através da indução de diversas respostas celulares tais como a morte celular, inflamação e stress oxidativo, tornando-se assim de extrema importância a utilização de modelos celulares in vitro para avaliar a resposta biológica desencadeada...