15 documents found, page 1 of 2
Cerebrovascular mechanism of bisphenol A exposure in stroke ischemic events
Costa, Henrique; Lorigo, Margarida; Cairrão, ElisaBackground: The endocrine-disrupting compound bisphenol A (BPA) is produced in large quantities all over the world and is found in epoxy resins and polycarbonate plastics, which are used to make baby bottles and food and drink storage containers [1]. Due to its androgenic and estrogenic qualities, BPA has been shown to accumulate in brain tissue and is thus linked to negative neurological and vascular outcomes,...
Vascular mechanisms of testosterone: the non-genomic point of view
Lorigo, Margarida; Mariana, Melissa; Lemos, Manuel C.; Cairrão, ElisaTestosterone (T) is the predominant endogenous androgen in the bloodstream. At the vascular level, T presents genomic and non-genomic effects, and both effects may overlap. The genomic actions assume that androgens can freely cross the plasma membrane of target cells and bind to nuclear androgen receptors, inducing gene transcription and protein synthesis. The non-genomic effects have a more rapid onset and may...
Vascular Pathways of Testosterone: Clinical Implications
Lorigo, Margarida; Mariana, Melissa; Oliveira, Nelson; Lemos, Manuel C.; Cairrão, ElisaCardiovascular diseases (CVD) are one of the leading causes of death worldwide. Testosterone (T) is an important sex hormone that triggers several genomic and non-genomic pathways, leading to improvements of several cardiovascular risk factors and quality of life in men. At the vascular level, the key effect of T is the vasorelaxation. This review discusses the molecular pathways and clinical implications of T ...
Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional...
Talhada, Daniela; Feiteiro, Joana; Costa, Ana Raquel; Talhada, Tiago; Cairrão, Elisa; Wieloch, Tadeusz; Englund, Elisabet; Santos, Cecilia ReisThe development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic mechanisms during the first weeks after stroke will influence functional outcome. Thyroid hormones (TH) are essential regulators of neuronal plasticity, however, their role in recovery related mechanisms of...
UV-B Filter Octylmethoxycinnamate Induces Vasorelaxation by Ca2+ Channel Inhibi...
Lorigo, Margarida; Antunes, Carla; Lemos, Manuel C.; Oliveira, J. Martinez de; Granadeiro, Luiza Breitenfeld; Cairrão, ElisaUltraviolet (UV) filters are chemicals widely used in personal care products (PCPs). Due to their effect as endocrine disruptor compounds (EDCs), the toxicity of UV filters is a current concern for human health. EDC exposure may be correlated to cardiovascular diseases (CVD), but to our knowledge, no studies assessed the UV filters effects as human EDCs at the vascular level. Octylmethoxycinnamate (OMC) is the ...
Antioxidants as stabilizers of UV filters: an example for the UV-B filter octyl...
Lorigo, Margarida; Cairrão, ElisaBackground: Sunlight is one of the main harmful exogenous factors that induce the reactive oxygen species formation. The human skin is the first line of photoprotection against harmful exogenous factors, such as UV radiations. The topical application of sunscreens, containing UV-B filters, is widely used to protect against UV-induced damage. Octylmethoxycinnamate is the world’s most widely used UV-B filter in s...
Variability of MMP/TIMP and TGF-β1 Receptors throughout the Clinical Progressio...
Serralheiro, Pedro; Novais, António; Cairrão, Elisa; Maia, Cláudio; Almeida, Carlos M. Costa; Verde, IgnacioChronic venous disease (CVeD) is a prevalent condition with a significant socioeconomic burden, yet the pathophysiology is only just beginning to be understood. Previous studies concerning the dysregulation of matrix metalloproteinases (MMPs) and their inhibitors (tissue inhibitors of metalloproteinases (TIMPs)) within the varicose vein wall are inconsistent and disregard clinical progression. Moreover, it is h...
Efeitos do TBT em células vasculares: estado da arte e trabalho futuro
Barros, Ana R.; Feiteiro, Joana; Cairrão, Elisa; Verde, Ignacio; Barroso, Carlos M.; Sousa, Ana C. A.O tributilestanho (TBT) é um contaminante ambiental com uma distribuição à escala mundial, considerado como um dos mais potentes disruptores endócrinos, sendo também considerado como um composto obesogénico e imunotóxico. Os seres humanos estão expostos a este e outros compostos orgânicos de estanhos de várias formas, sendo a ingestão de alimentos, especialmente peixe e marisco, e de água da rede pública, vias ...
Effects of Di-(2-ethylhexyl) phthalate on vascular smooth muscle cells
Mariana, Melissa; Cairrão, Elisa; Verde, IgnacioEvery year million tons of plastic are produced around the world and humans are increasingly exposed to them. This constant exposure has raised some concerns against human health and substances leaching from plastics, such as phthalates. These compounds, used to give flexibility to polyvinyl chloride (PVC), are endocrine-disrupting compounds because they have the ability to interfere with hormone pathways. Phth...
Efeito do Bisfenol A na regulação da contração da artéria umbilical humana
Oliveira, Nádia; Feiteiro, Joana; Cairrão, Elisa; Verde, IgnacioO bisfenol A (BPA) é um composto orgânico largamente utilizado na indústria de plásticos, tintas / vernizes, materiais de conexão e materiais de enchimento. É também utilizado como retardador de chamas, fluidos para travões e papéis térmicos. O BPA é maioritariamente utilizado na produção de plásticos (~ 3,8 milhões de toneladas por ano), incluindo embalagens de alimentos, brinquedos, monómeros odontológicos e ...