6 documents found, page 1 of 1
Comorbidities and menopause assessment in women living with HIV
Caixas, Umbelina; Tariq, Shema; Morello, Judit; Dragovic, Gordana; Lourida, Giota; Hachfeld, Anna; Nwokolo, NnekaFundingThis work was supported by European AIDS Clinical Society.; Women living with HIV are reaching older age and experiencing menopause and age-related comorbidities. Data suggest that women living with HIV experience earlier menopause and more menopausal symptoms and age-related comorbidities compared to women without HIV. However, there are no guidelines on the screening for and management of age-related c...
High Instantaneous Inhibitory Potential of Bictegravir and the New Spiro-β-Lact...
Bártolo, Inês; Moranguinho, Inês; Gonçalves, Paloma; Diniz, Ana Rita; Borrego, Pedro; Martin, Francisco; Figueiredo, Inês; Gomes, PerpétuaFunding Information: This work was supported by Fundação para a Ciência e Tecnologia (FCT), Portugal, Aga Khan Development Network (AKDN)–Portugal Collaborative Research Network in Portuguese-speaking countries in Africa (project 332821690). CQC is supported by FCT through projects UIDB/00313/2020 and UIDP/QUI/00313/2020, co-funded by COMPETE2020-UE. iMed.ULisboa, Faculdade de Farmácia da Universidade de Lisboa...
Differences in nevirapine biotransformation as a factor for its sex-dependent d...
Marinho, Aline T.; Rodrigues, Patrícia M.; Caixas, Umbelina; Antunes, Alexandra M.M.; Branco, Teresa; Harjivan, Shrika G.; Marques, M. MatildeFunding Information: This work was supported by Fundac¸ão para a Ciência e a Tecnologia (FCT, Portugal), through research grants (PTDC/SAU-TOX/111663/2009, PTDC/ QUI-QUI/113910/2009, SFRH/BD/80690/2011 to S. G. H.) and strategic funding to Centro de Química Estrutural (PEst-OE/QUI/UI0100/2013).; Objectives: Nevirapine is widely used for the treatment of HIV-1 infection; however, its chronic use has been associa...
Monitoring abacavir bioactivation in humans
Grilo, Nádia M.; Antunes, Alexandra M.M.; Caixas, Umbelina; Marinho, Aline T.; Charneira, Catarina; Conceição Oliveira, M.; Monteiro, E.C.Funding Information: This work was supported by Fundação para a Ciência e a Tecnologia (FCT, Portugal) , through research grants ( PTDC/SAU-TOX/111663/2009 and PTDC/QUI-QUI/113910/2009 ), and pluriannual funds to Centro de Química Estrutural ( PEst-OE/QUI/UI0100/2011 ).; The anti-HIV drug abacavir is associated with idiosyncratic hypersensitivity reactions and cardiotoxicity. Although the mechanism underlying a...
Long-term maraviroc use as salvage therapy in HIV-2 infection
Caixas, Umbelina; Ferreira, Joana; Marinho, Aline T.; Faustino, Inês; Grilo, Nádia M.; Lampreia, Fátima; Germano, Isabel; Monteiro, E.C.; SA, Pereira
Baseline susceptibility of primary HIV-2 to entry inhibitors
Borrego, Pedro; Calado, Rita; Marcelino, José M.; Bártolo, Inês; Rocha, Cheila; Cavaco-Silva, Patrícia; Doroana, Manuela; Antunes, FranciscoBackground: The baseline susceptibility of primary HIV-2 to maraviroc (MVC) and other entry inhibitors is currently unknown. Methods: The susceptibility of 19 HIV-2 isolates obtained from asymptomatic and AIDS patients and seven HIV-1 clinical isolates to the fusion inhibitors enfuvirtide (ENF) and T-1249, and to the coreceptor antagonists AMD3100, TAK-779 and MVC, was measured using a TZM-bl cell-based assay. ...