7 documents found, page 1 of 1
Inglês Inglês
da Fonseca, Beatriz Velosa; Mendes Veiga, Maria Isabel; Baptista, Vitória; Pernaute-Lau, Leyre; Osório, Nuno; Calçada, CarlaMalaria, a devastating illness remains a global health concern with an estimated 249 million malaria cases in 85 malaria-endemic countries around the world. Malaria elimination, challenged by drug resistance, requires strategic interventions that could be the implementation of antimalarials with selective actions on the different phases of the parasite life cycle. Of particular relevance is gametocytocidal drug...
Inglês Inglês
da Fonseca, Beatriz Velosa; Mendes Veiga, Maria Isabel; Baptista, Vitória; Pernaute-Lau, Leyre; Osório, Nuno; Calçada, CarlaMalaria, a devastating illness remains a global health concern with an estimated 249 million malaria cases in 85 malaria-endemic countries around the world. Malaria elimination, challenged by drug resistance, requires strategic interventions that could be the implementation of antimalarials with selective actions on the different phases of the parasite life cycle. Of particular relevance is gametocytocidal drug...
Optical spectrophotometry as a promising method for quantification and tage dif...
Baptista, Vitória; Silva, Miguel; Ferreira, Gabriel M; Calçada, Carla; Minas, Graça; Veiga, Maria Isabel; Catarino, Susana OliveiraMalaria is one of the most life-threatening infectious diseases worldwide, claiming half a million lives yearly. Prompt and accurate diagnosis is crucial for disease control and elimination. Currently used diagnostic methods require blood sampling and fail to detect low-level infections. At the symptomatic stage of infection, the parasites feed on red blood cells' (RBCs) hemoglobin, forming inert crystals, the ...
Plasmodium falciparum heme species dynamics under antimalarial exposure
Baptista, Vitória Cunha; Silva, Miguel; Calçada, Carla; Esho, Ruth; Catarino, Susana Oliveira; Veiga, Maria IsabelWhile the recently approved first malaria vaccine provides new hope with a reduction in deadly severe malaria, decreasing the disease burden towards elimination requires highly effective drug treatment. However, treatment efficacy is constantly challenged by the capacity of Plasmodium falciparum parasites to develop resistance. The present artemisinin-based combination therapy is no exception. As the portfolio ...
OmniSARS2: A Highly Sensitive and Specific RT-qPCR-Based COVID-19 Diagnostic Me...
Carvalho-Correia, Eduarda; Calçada, Carla; Branca, Fernando; Estévez-Gómez, Nuria; De Chiara, Loretta; Varela, Nair; Gallego-García, PilarExtensive transmission of SARS-CoV-2 during the COVID-19 pandemic allowed the generation of thousands of mutations within its genome. While several of these become rare, others largely increase in prevalence, potentially jeopardizing the sensitivity of PCR-based diagnostics. Taking advantage of SARS-CoV-2 genomic knowledge, we designed a one-step probe-based multiplex RT-qPCR (OmniSARS2) to simultaneously detec...
Expansion of a Specific Plasmodium falciparum PfMDR1 Haplotype in Southeast Asi...
Calçada, Carla; Silva, Miguel; Baptista, Vitória; Thathy, Vandana; Silva-Pedrosa, Rita; Granja, Diana; Ferreira, Pedro Eduardo; Gil, José PedroArtemisinin-based combination therapies (ACTs) have been vital in reducing malaria mortality rates since the 2000s. Their efficacy, however, is threatened by the emergence and spread of artemisinin resistance in Southeast Asia. The Plasmodium falciparum multidrug resistance protein 1 (PfMDR1) transporter plays a central role in parasite resistance to ACT partner drugs through gene copy number variations (CNV) a...
New drugs from traditional medicines: pharmacological evaluation of plant extra...
Pinho, Cláudia; Oliveira, Ana; Paraíso, Nilson; Carvalho, Ana C.; Calçada, Carla; Lima, Cristovao F.; Dias, Alberto C.P.Plants are rich sources of medicines and Brazil is among the most biodiverse nations in the world.