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Novel Donepezil-Arylsulfonamide Hybrids as Multitarget-Directed Ligands for Pot...

Queda, Fausto; Calò, Sonia; Gwizdala, Karolina; Magalhães, João D.; Cardoso, Sandra M.; Chaves, Sílvia; Piemontese, Luca; Santos, M. Amélia

Alzheimer's disease (AD) is one of the most devastating neurodegenerative disorders, characterized by multiple pathological features. Therefore, multi-target drug discovery has been one of the most active fields searching for new effective anti-AD therapies. Herein, a series of hybrid compounds are reported which were designed and developed by combining an aryl-sulfonamide function with a benzyl-piperidine moie...

Date: 2021   |   Origin: Estudo Geral - Universidade de Coimbra
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