139 documents found, page 1 of 14
Impact of neutrophil-activating protein conservation on diagnostic tests and va...
Diogo Gonçalves, Lídia Maria; Almeida, António J.; Calado, CecíliaBACKGROUND: The neutrophil activating protein (NAP) is a highly immunogenic and virulence factor of Helicobacter pylori, presenting inflammatory and immunomodulatory activity. Consequently, NAP has been explored as a diagnostic and therapeutic target. However, when evaluating a target protein to design diagnostic methods or vaccines, it is critical to determine the protein conservation among the bacterial popul...
Cytokine-based insights into bloodstream infections and bacterial gram typing i...
Araújo, Rúben Alexandre Dinis; Ramalhete, Luís; Von Rekowski, Cristiana; Henrique Fonseca, Tiago Alexandre; Calado, Cecília; Bento, LuísTimely and accurate identification of bloodstream infections (BSIs) in intensive care unit (ICU) patients remains a key challenge, particularly in COVID-19 settings, where immune dysregulation can obscure early clinical signs. Methods: Cytokine profiling was evaluated to discriminate between ICU patients with and without BSIs, and, among those with confirmed BSIs, to further stratify bacterial infections by Gra...
Integration of FTIR spectroscopy and machine learning for kidney allograft reje...
Ramalhete, Luís; Araújo, Rúben Alexandre Dinis; Bigotte Vieira, Miguel; Vigia, Emanuel; Aires, Inês; Ferreira, Aníbal; Calado, CecíliaKidney transplantation is a life-saving treatment for end-stage kidney disease, but allograft rejection remains a critical challenge, requiring accurate and timely diagnosis. The study aims to evaluate the integration of Fourier Transform Infrared (FTIR) spectroscopy and machine learning algorithms as a minimally invasive method to detect kidney allograft rejection and differentiate between T Cell-Mediated Reje...
Chitosan nanoparticles for enhanced immune response and delivery of multi-epito...
Amaral, Rita; Concha, Tomás; Vítor, Jorge; Almeida, António J.; Calado, Cecília; Diogo Gonçalves, Lídia MariaHelicobacter pylori is the leading cause of chronic gastritis, peptic ulcer, gastric adenocarcinoma, and mucosal-associated lymphoma. Due to the emerging problems with antibiotic treatment against H. pylori in clinical practice, H. pylori vaccination has gained more interest. Oral immunization is considered a promising approach for preventing initial colonization of this bacterium in the gastrointestinal tract,...
Comparison of two metabolomics-platforms to discover biomarkers in critically i...
Fonseca, Tiago A.H.; Von Rekowski, Cristiana P.; Araújo, Rúben; Oliveira, M. Conceição; Justino, Gonçalo C.; Bento, Luís; Calado, CecíliaFunding Information: This research was funded by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT), grant numbers DSAIPA/DS/0117/2020 and RNEM-LISBOA-01-0145-FEDER-022125 (Portuguese Mass Spectrometry Network). Centro de Qu\u00EDmica Estrutural is a Research Unit funded by FCT through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by FCT...
Analysis of six consecutive waves of ICU-admitted COVID-19 patients
Von Rekowski, Cristiana P.; Pinto, Iola; Fonseca, Tiago A.H.; Araújo, Rúben; Calado, Cecília; Bento, LuísFunding Information: Open access funding provided by FCT|FCCN (b-on). This research was supported by national funds through the Funda\u00E7\u00E3o para a Ci\u00EAncia e Tecnologia (FCT), I.P., under the following grants: DSAIPA/DS/0117/2020, UIDB/00297/2020 ( https://doi.org/ https://doi.org/10.54499/UIDB/00297/2020 ) and UIDP/00297/2020 ( https://doi.org/ https://doi.org/10.54499/UIDP/00297/2020 ). Publisher C...
Predictive Models of Patient Severity in Intensive Care Units Based on Serum Cy...
Von Rekowski, Cristiana; AH Fonseca, Tiago; Araújo, Rúben; Martins, Ana; Pinto, Iola; Oliveira, M. Conceição; Justino, Gonçalo C.; Bento, LuísFunding Information: This research was supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia (FCT), grant numbers DSAIPA/DS/0117/2020 and RNEM-LISBOA-01-0145-FEDER-022125 (Portuguese Mass Spectrometry Network). Centro de Qu\u00EDmica Estrutural is a Research Unit funded by FCT through projects UIDB/00100/2020 and UIDP/00100/2020. Institute of Molecular Sciences is an Associate Laboratory funded by ...
Integration of FTIR Spectroscopy and Machine Learning for Kidney Allograft Reje...
Ramalhete, Luís; Araújo, Rúben; Bigotte Vieira, Miguel; Vigia, Emanuel; Aires, Inês; Ferreira, Anibal; Calado, CecíliaPublisher Copyright: © 2025 by the authors.; Background: Kidney transplantation is a life-saving treatment for end-stage kidney disease, but allograft rejection remains a critical challenge, requiring accurate and timely diagnosis. The study aims to evaluate the integration of Fourier Transform Infrared (FTIR) spectroscopy and machine learning algorithms as a minimally invasive method to detect kidney allograft...
Cytokine-Based Insights into Bloodstream Infections and Bacterial Gram Typing i...
Araújo, Rúben; Ramalhete, Luís; Von Rekowski, Cristiana; Fonseca, Tiago AH; Calado, Cecília; Bento, LuísFunding Information: This research was funded by project grant DSAIPA/DS/0117/2020, supported by Funda\u00E7\u00E3o para a Ci\u00EAncia e a Tecnologia, Portugal, and IPL/IDI&CA2024/R-DICIP_ISEL by Instituto Polit\u00E9cnico de Lisboa, Portugal. The present work was conducted in Instituto Polit\u00E9cnico de Lisboa and in the Engineering & Health Laboratory, resulting from a collaboration protocol established be...
Analyzing Heart Rate Variability for COVID-19 ICU Mortality Prediction Using Co...
De Azevedo David, Guilherme; Lourenço, André; Von Rekowski, Cristiana; Pinto, I. M.; Calado, Cecília; Bento, LuísFunding Information: This research was supported by national funds through the Fundação para a Ciência e Tecnologia (FCT), I.P., under the following grants: DSAIPA/DS/0117/2020, UIDB/00297/2020 (https://doi.org/10.54499/UIDB/00297/2020), UIDP/00297/2020 (https://doi.org/10.54499/UIDP/00297/2020) (Center for Mathematics and Applications), project with reference 2023.01951.BD and DOI: https://doi.org/10.54499/202...