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Calciphylaxis in Pre-dialysis Chronic Kidney Disease: Case Report
Ferreira,André; Calado,Rebeca; Cardoso,José Carlos; Galvão,Ana; Alves,RuiAbstract Calciphylaxis is a rare life‑threatening vasculopathy resulting from calcium deposition in the arteriolar microvasculature of the deep dermis and subcutaneous adipose tissue, mainly occurring in end‑stage kidney disease (ESKD) treated with maintenance dialysis. Calciphylaxis in patients without ESKD is even rarer, which makes the diagnosis of calciphylaxis challenging in this population. In patients wi...
Zinc supplementation possibly resolving pancreatic metastatic tumor-associated ...
Matos,Ana L.; Flor,Duarte; Calado,Rebeca; Cardoso,José C.Abstract Necrolytic migratory erythema (NME) is a rare skin disease typically associated with glucagonoma syndrome, although it can be associated with other non-tumoral diseases. We present the case of a 71-year-old man with a pancreatic neuroendocrine tumor diagnosed with ENM. Although zinc levels were normal, after zinc oral supplementation, there was complete resolution of NME lesions that persisted even aft...
Epidermal Barrier Dysfunction in Atopic Dermatitis
Gomes,Tiago Fernandes; Calado,Rebeca; Gonçalo,MargaridaABSTRACT Impaired skin barrier is one of the hallmarks of atopic dermatitis (AD), with abnormalities in the cornified envelope, lipid lamellae, tight junctions and cutaneous microbiome. These findings are also present in nonlesional skin of AD individuals, suggesting that epidermal barrier defects may be the initial step towards the development of AD and eventually other atopic diseases (atopic march). It is cu...