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Adult B-Cell Acute Lymphoblastic Leukemia Cells Display Decreased PTEN Activity...
Gomes, AM; Soares, M; Ribeiro, P; Caldas, J; Póvoa, V; Martins, L; Melão, A; Serra-Caetano, A; Botelho de Sousa, A; Lacerda, J; Barata, JAdult B-cell acute lymphoblastic leukemia remains a major therapeutic challenge, requiring a better characterization of the molecular determinants underlying disease progression and resistance to treatment. Here, using a phospho-flow cytometry approach we show that adult diagnostic B-cell acute lymphoblastic leukemia specimens display PI3K/Akt pathway hyperactivation, irrespective of their BCR-ABL status and de...
Polymerase Chain Reaction Screening for Fungemia and/or Invasive Fungal Infecti...
Ribeiro, P; Costa, F; Monteiro, A; Caldas, J; Silva, M; Ferreira, G; Veiga, J; Sousa, MO; Viegas, MP; Santos, E; Gonçalves, AJ; Botelho de Sousa, AINTRODUCTION: Invasive fungal infections (IFIs) are a life-threatening complication in patients with hematologic malignancies, mainly in acute leukemia patients, following chemotherapy. IFI incidence is increasing, and associated mortality remains high due to unreliable diagnosis. Antifungal drugs are often limited by inadequate antimicrobial spectrum and side effects. Thus, the detection of circulating fungal ...
Hemorragia do Psoas-Ilíaco em Doentes com Hemofilia. Experiência do Serviço de ...
Santos, N; Caldas, J; Antunes, M; Diniz, MJ
Hemiplegia e amputação: avaliação funcional
Laíns, J; Azenha, A; Caldas, J
Depressão e ansiedade na revaliazação do hemiplégico de causa vascular
Laíns, J; Oliveira, RA; Caldas, J; Azenha, A; Keating, J