9 documents found, page 1 of 1
Dedicated Pediatricians in Emergency Department: Shorter Waiting Times and Lowe...
Melo, MR; Ferreira-Magalhães, M; Flor-Lima, F; Rodrigues, M; Severo, M; Almeida-Santos, L; Caldas-Afonso, A; Barros, P; Ferreira, ABackground Dedicated pediatricians in emergency departments (EDs) may be beneficial, though no previous studies have assessed the related costs and benefits/harms. We aimed to evaluate the net benefits and costs of dedicated emergency pediatricians in a pediatric ED. Methods Cost-consequences analysis of visits to a pediatric ED of a tertiary hospital. Two pediatric ED Medical Teams (MT) were compared: MT-A (Ma...
Oxidative stress and nitric oxide are increased in obese children and correlate...
Correia-Costa, L; Sousa, T; Morato, M; Cosme, D; Afonso, J; Areias, JC; Schaefer, F; Guerra, A; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, AOxidative stress and nitric oxide (NO) appear to represent important links between obesity and cardiovascular, metabolic and/or renal disease. We investigated whether oxidative stress and NO production/metabolism are increased in overweight and obese prepubertal children and correlate with cardiometabolic risk and renal function. We performed a cross-sectional evaluation of 313 children aged 8-9 years. Anthropo...
Urinary fibrogenic cytokines ET-1 and TGF-beta 1 are associated with urinary an...
Correia-Costa, L; Morato, M; Sousa, T; Cosme, D; Guimaraes, JT; Guerra, A; Schaefer, F; Caldas-Afonso, A; Azevedo, A; Albino-Teixeira, ABACKGROUND:Fibrogenic cytokines are recognized as putative drivers of disease activity and histopathological deterioration in various kidney diseases. We compared urinary transforming growth factor β1 (U-TGF-β1) and endothelin 1 (U-ET-1) levels across body mass index classes and assessed their association with the level of urinary angiotensinogen (U-AGT), a biomarker of intrarenal renin-angiotensin-aldosterone ...
Determinants of carotid-femoral pulse wave velocity in prepubertal children
Correia-Costa, A; Correia-Costa, L; Caldas-Afonso, A; Schaefer, F; Guerra, A; Moura, C; Mota, C; Barros, H; Areias, JC; Azevedo, ABACKGROUND: Pulse wave velocity (PWV) is a noninvasive technique to evaluate arterial stiffness, a dynamic property of the vessels, reflecting their structure and function. Childhood obesity is associated with several cardiovascular comorbidities and to the progression of atherosclerosis. We aimed to compare carotid-femoral PWV between normal weight and overweight/obese prepubertal children and to quantify its ...
Gender and obesity modify the impact of salt intake on blood pressure in children
Correia-Costa, L; Cosme, D; Nogueira-Silva, L; Morato, M; Sousa, T; Moura, C; Mota, C; Guerra, A; Albino-Teixeira, A; Areias, JC; Schaefer, F; Lopes, CBACKGROUND:Most modifiable risk factors for high blood pressure (BP), such as obesity and salt intake, are imprinted in childhood and persist into adulthood. The aim of our study was to evaluate the intake of salt in children and to assess its impact on BP taking into account gender and nutritional status. METHODS:A total of 298 children aged 8-9 years were evaluated in a cross-sectional study. Anthropometric m...
Normalization of glomerular filtration rate in obese children
Correia-Costa, L; Schaefer, F; Caldas-Afonso, A; Bustorff, M; Guimaraes, JT; Guerra, A; Barros, H; Azevedo, ABACKGROUND:Glomerular filtration rate (GFR) is conventionally indexed to body surface area (BSA), but this may lead to biased results when applied to subjects of abnormal body size. The aim of our study was to examine the impact of normalization to the BSA and alternative body size descriptors on measured and estimated GFR in overweight and obese children. METHODS:This was a cross-sectional study of 313 childre...
Decreased renal function in overweight and obese prepubertal children
Costa, L; Caldas-Afonso, A; Schaefer, F; Guimarães, JT; Bustorff, M; Guerra, A; Barros, H; Azevedo, ABACKGROUND: Obesity is a potentially modifiable risk factor for the development and progression of kidney disease, both in adults and children. We aim to study the association of obesity and renal function in children, by comparing estimated glomerular filtration rate (eGFR) in nonoverweight and overweight/obese children. Secondarily, we aim to evaluate the accuracy of equations on eGFR estimation when compared...
Sex-Specific Mediating Role of Insulin Resistance and Inflammation in the Effec...
Costa, L; Santos, AC; Severo, M; Guerra, A; Azevedo, A; Caldas-Afonso, A; Barros, H; Schaefer, FObjective: To evaluate the association between obesity indices and blood pressure (BP) at 4 years of age, in each sex, and to quantify to which extent this association is mediated by inflammation and insulin resistance (IR). Materials and Methods: We studied 1250 4-year-old children selected from the population-based birth cohort Generation XXI. Associations between body mass index (BMI) z-score and waist-to-he...
Growth cartilage expression of growth hormone/insulin-like growth factor I axis...
Brito, I; Gil-Peña, H; Molinos, I; Loredo, V; Tiago Henriques-Coelho; Caldas-Afonso, A; Santos, FIntroduction: Catch-up growth following the cessation of a growth inhibiting cause occurs in humans and animals. Although its underlying regulatory mechanisms are not well understood, current hypothesis confer an increasing importance to local factors intrinsic to the long bones' growth plate (GP). Aim: The present study was designed to analyze the growth-hormone (GH)-insulin-like growth factor I (IGF-I) axis i...