2 documents found, page 1 of 1
Evaluation of RRAS2 and TTP1 promoter mutations in thyroid tumours
Leite, Rúben; Dias, Carolina; Soares, Paula; Vinagre, JoãoThyroid cancer is the most frequent endocrine neoplasm, being the tenth most prevalent in both genders and it presenting an overall good prognosis [1]. Ras related 2 (R-Ras2), also known as TC21, is a GTP-binding protein that together with R-Ras1 and R-Ras3, is part of the R-Ras GTPase subfamily. Mutations in RRAS2 gene in the long-tailed hotspot Q72L/H block the hydrolysis of guanosine triphosphate (GTP) in Ra...
Generation of an obese diabetic mouse model upon conditional Atrx disruption
Gaspar, Tiago Bordeira; Jesus, Tito Teles; Azevedo, Maria Teresa; Macedo, Sofia; Soares, Mariana Alves; Martins, Rui Sousa; Leite, Rúben; Rodrigues, LiaATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...