18 documents found, page 1 of 2
Outbreak of monkeypox in an STD clinic in Lisbon
Caldeira, M.; Fernandes, C.; Neves, J.; João, A.; Calado, R.; Pinto, A.R.; Borrego, M.J.; Cordeiro, R.; Machado, J.; Pelerito, A.; Lopes de Carvalho, I.We present the preliminary results of the first 43 patients with a definitive diagnosis of human infection with monkeypox virus, from the dermatovenereology department of Hospital Santo António dos Capuchos, Lisbon, in May 2022 [...].
Dupilumab Treatment in Atopic Dermatitis: Real-World Evidence from a Portuguese...
Pessoa e Costa, Tomás; Duarte, B.; Caldeira, M.; Rocha Páris, M.; Paiva-Lopes, M. J.Introduction: Dupilumab is a fully human monoclonal antibody that blocks interleukin-4 and interleukin-13, key drivers of type 2 helper T-cell (Th2)-mediated inflammatory response. It was the first biologic treatment approved for adult patients with inadequately-controlled moderate-to-severe atopic dermatitis (AD). Continuous collection of daily data practice is important in order to evaluate the real effective...
Organizational maturity and projects performance: The mediation of benefits man...
Romão, M.; Carvalho, H.; Caldeira, M.; Gomes, J.Nowadays the investments made by organizations to get better business performances are crucial and difficult to obtain. So, it́s more and more important that the business-cases underline not only the shortterm objectives, but also the long-term benefits that promotes a sustainable future for organizations and investors. The main objective of our research is to study how investments on IS/IT influence projects p...
Information and communication technology adoption for business benefits: a case...
Caldeira, M.; Serrano, A.; Quaresma, R.; Pedron, C.; Romão, M.his case study analyses the benefits of implementing a paperless software solution (Alert (R) pfh-Alert Paperfree Hospital, developed by Alert Life Sciences Computing) in a Portuguese Hospital, the Espirito Santo Hospital, in the city of Evora. Alert (R) pfh is a complete hospital clinical information system with real time clinical information input. It was implemented in emergency medical services, inpatient a...
Allergic asthma exhaled breath metabolome: a challenge for comprehensive two-di...
Caldeira, M.; Perestrelo, Rosa Maria de Sá; Barros, António S.; Bilelo, M. J.; Morête, A.; Câmara, J. S.; Rocha, Sílvia M.Allergic asthma represents an important public health issue, most common in the paediatric population, characterized by airway inflammation that may lead to changes in volatiles secreted via the lungs. Thus, exhaled breath has potential to be a matrix with relevant metabolomic information to characterize this disease. Progress in biochemistry, health sciences and related areas depends on instrumental advances, ...
Profiling allergic asthma volatile metabolic patterns using a headspace-solid ph...
Caldeira, M.; Barros, António S.; Bilelo, M. J.; Parada, A.; Câmara, J. S.; Rocha, Sílvia M.Allergicasthmarepresentsanimportantpublichealthissuewithsignificantgrowthovertheyears,especially in the paediatric population. Exhaled breath is a non-invasive, easily performed and rapid method forobtainingsamplesfromthelowerrespiratorytract.Inthepresentmanuscript,themetabolicvolatile profiles of allergic asthma and control children were evaluated by headspace solid-phase microextraction combined with gas chroma...
Sources of hepatic triglyceride accumulation during high-fat feeding in the hea...
Delgado, T. C.; Pinheiro, D.; Caldeira, M.; Castro, M. M. C. A.; Geraldes, C. F. G. C.; López-Larrubia, P.; Cerdán, S.; Jones, J. G.Hepatic triglyceride (HTG) accumulation from peripheral dietary sources and from endogenous de novo lipogenesis (DNL) was quantified in adult Sprague-Dawley rats by combining in vivo localized 1H MRS measurement of total hepatic lipid with a novel ex vivo 2H NMR analysis of HTG 2H enrichment from 2H-enriched body water. The methodology for DNL determination needs further validation against standard methodologie...
A Qualidade dos Dados de Observação em Engenharia Civil
Lucas, A.; Palma-dos-Reis, A.; Caldeira, M.Neste artigo apresenta-se o trabalho desenvolvido e discutem-se as conclusões obtidas relativamente à identificação e definição das dimensões da qualidade dos dados relativos ao controlo da segurança de grandes obras de engenharia civil. A análise do comportamento e o controlo da segurança daquelas obras depende, fundamentalmente, da qualidade dos dados recolhidos através de sensores, denominados dados de obser...
The quality of monitoring data in civil engineering works
Lucas, A.; Palma-dos-Reis, A.; Caldeira, M.This paper presents the research and discusses the findings concerning the identification and definition of quality dimensions related to the monitoring data obtained in the safety control of major civil engineering works, namely dams and bridges. The analysis of the behavior and the safety evaluation of these works essentially depend on the quality of the data collected by the sensors, named the observation da...
Development of a dynamic headspace solid-phase microextraction procedure couple...
Rodrigues, F.; Caldeira, M.; Câmara, J. S.In the present study, a simple and sensitive methodology based on dynamic headspace solid-phase microextraction (HS-SPME) followed by thermal desorption gas chromatography with quadrupole mass detection (GC–qMSD), was developed and optimized for the determination of volatile (VOCs) and semi-volatile (SVOCs) compounds from different alcoholic beverages: wine, beer and whisky. Key experimental factors influencing...