3 documents found, page 1 of 1
Comparison of the serum whole molecular composition with the serum metabolome t...
Correia, Inês; Henrique Fonseca, Tiago Alexandre; Pataco, Jéssica; Oliveira, Mafalda; Caldeira, Viviana; Domingues, N.; Von Rekowski, CristianaOmics Sciences serve as an essential tool to advance precision medicine. Since conventional omics sciences rely on laborious, complex and time-consuming analytical processes, this study evaluated whether the serum molecular fingerprint, captured by FTIR spectroscopy, could predict mortality risk in critically ill patients. Both the whole serum and the serum metabolome (i.e., serum after removal of macromolecule...
A new method for a rapid and high-throughput comparison of molecular profiles a...
Caldeira, Viviana; Fonseca, Tiago AH; N'Dembo, Luana; Araújo, Rúben; Von Rekowski, Cristiana; Sampaio, Pedro; Calado, CecíliaTo robustly discover and explore phytocompounds, it is necessary to evaluate the interrelationships between the plant species, plant tissue, and the extraction process on the extract composition and to predict its cytotoxicity. The present work evaluated how Fourier Transform InfraRed spectroscopy can acquire the molecular profile of aqueous and ethanol-based extracts obtained from leaves, seeds, and flowers of...
Predict cells viability, proliferation, and metabolic status, based in one uniq...
Caldeira, Viviana; Araújo, Rúben; Ramalhete, Luís; Calado, CecíliaA new method to simultaneously predict cells viability, proliferation and metabolic status, in a rapid, simple but also specific and sensitive mode was developed. The method is based on mid-infrared (MIR) spectroscopic analysis of cells. As model system were used Human embryonic kidney (HEK) 293 cells and T lymphocytes. After submitting cells to different environments as the toxic dimethyl sulfoxide, or metabol...