4 documents found, page 1 of 1
Hybrid Deep Brain Stimulation for Parkinson’s Disease and Dystonia Improves Sid...
Costa, Diogo; Calejo, Margarida; Vila-Chã, Nuno; Damásio, Joana; Silva, Carla; Procaci da Cunha, Eduardo; Botelho, Luís; Verdelho, AntónioIntroduction: Deep brain stimulation (DBS) in movement disorders does not always achieve optimal symptomatic control. Most common issues involve suboptimal electrode positioning and target stimulation and troublesome side effects limiting the therapeutic window. Recently approved implantable pulse generators (IPG) allow for pulse widths lower than 60 μs, increasing the therapeutic window, and current steering. ...
Screening of Distal Symmetric Polyneuropathy in Hospitalized Diabetic Patients
Gonçalves, Helena; Lopes, Ana; Costa, Andreia; Calvão, Joana; Fonseca, Liliana; Gonçalves, João; Branco, Catarina; Martins, Raquel; Barbosa, VeraIntroduction: Distal symmetric polyneuropathy (DSPN) isa frequent, catastrophic and underdiagnosed complication ofdiabetes mellitus. The authors have hypothesized that hospitalization could be an opportunity to screen DSPN and alsopretend to compare two different diagnostic methods.Material and Methods: This was a prospective and multicentre study that enrolled diabetic patients admitted consecutively to intern...
Pregnancy Outcomes in Portuguese Women with Multiple Sclerosis: The PREGNIMS Study
Novo, Ana; Castelo, Juliana; de Sousa, Ary; Amorim, Isabe; Alves, José Nuno; Calejo, Margarida; Monteiro, Ana; Arenga, Marta; Shamasna, MotasemINTRODUCTION: Several questions about pregnancy in women with multiple sclerosis (MS) have been discussed, but clarification is still needed in some very practical issues. Portuguese data on this subject remain scattered and need to be analyzed in order to standardize clinical practice. OBJECTIVE: This study aimed to describe and analyze the impact of MS on pregnancy and perinatal health of children born to Por...
Late‐onset Levodopa Responsive Parkinsonism Due to Polymerase γ 1 Mutations
Calejo, Margarida; Vilarinho, Laura; Neiva, Raquel; Botelho, Luís; Ramalheira, João; Taipa, Ricardo; Melo‐Pires, Manuel; Lima, António BastosIntroduction: Polymerase γI (POLG) gene mutations may induce mitochondrial DNA (mtDNA) instability leading to its depletion or multiple deletions1 and causing a wide spectrum of multisystemic disorders. Commonly described phenotypes include AlpersHuttenlocher syndrome, childhood myocerebrohepatopathy, myoclonic epilepsy myopathy and sensory ataxia, mitochondrial recessive ataxia syndrome, sensory ataxia neuropa...