43 documents found, page 1 of 5
Advancing Access to Intestinal Microbiota Transplant: Bridging the Gap Between ...
Dinis, L; Pinheiro, H; Póvoa, P; Calhau, C; Pestana, D; Marques, CClostridioides difficile is an opportunistic pathogen that can cause a range of conditions, from asymptomatic carriage to severe illness, posing a significant public health threat due to its high mortality rates and substantial healthcare costs. Traditional treatment options, including antibiotics, often fail to eradicate the infection, leading to recurrent cases that severely impact patients' lives. Intestinal...
Case report: Primary CDK4/6 inhibitor and endocrine therapy in locally advanced...
Vilhais, G; Alpuim Costa, D; Fontes-Sousa, M; Ribeiro, PC; Martinho, F; Botelho de Sousa, C; Santos, CR; Negreiros, I; Canastra, A; Borralho, PLocally advanced breast cancer poses significant challenges to the multidisciplinary team, in particular with hormone receptor (HR) positive, HER2- negative tumors that classically yield lower pathological complete responses with chemotherapy. The increasingly significant use of CDK 4/6 inhibitors (CDK4/6i) plus endocrine therapy (ET) in different breast cancer settings has led to clinical trials focusing on th...
Biochemical and Anthropometric Outcomes in Paediatric Patients with Heterozygou...
Peres, M; Moreira-Rosário, A; Padeira, G; Gaspar Silva, P; Correia, C; Nunes, A; Garcia, E; Faria, A; Teixeira, D; Calhau, C; Pereira-da-Silva, LThe COVID-19 pandemic lockdowns affected the lifestyles of children and adolescents, leading to an increase in childhood obesity. Paediatric patients with familial hypercholesterolemia (FH) may be more susceptible to lockdown effects due to their increased cardiovascular risk. However, data are lacking. We investigated the effect of lockdowns on the metabolic profile of paediatric patients with FH. Blood lipids...
Body Composition Evaluation and Clinical Markers of Cardiometabolic Risk in Pat...
Luengo-Pérez, LM; Fernández-Bueso, M; Ambrojo, A; Guijarro, M; Ferreira, AC; Pereira-da-Silva, L; Moreira-Rosário, A; Faria, A; Calhau, C; Daly, ACardiovascular diseases are the main cause of mortality worldwide. Patients with phenylketonuria (PKU) may be at increased cardiovascular risk. This review provides an overview of clinical and metabolic cardiovascular risk factors, explores the connections between body composition (including fat mass and ectopic fat) and cardiovascular risk, and examines various methods for evaluating body composition. It parti...
Changes in Microbiota Profile in the Proximal Remnant Intestine in Infants Unde...
Barreiros-Mota, I; R. Araújo, J; Marques, C; Sousa, L; Morais, J; Castela, I; Faria, A; Neto, MT; Cordeiro-Ferreira, G; Virella, D; Pita, AEarly-life gut dysbiosis has been associated with an increased risk of inflammatory, metabolic, and immune diseases later in life. Data on gut microbiota changes in infants undergoing intestinal surgery requiring enterostomy are scarce. This prospective cohort study examined the enterostomy effluent of 29 infants who underwent intestinal surgery due to congenital malformations of the gastrointestinal tract, nec...
The impact of Hafnia alvei HA4597™ on weight loss and glycaemic control after b...
Ismael, S; Vaz, C; Durao, C; Silvestre, MP; Calhau, C; Teixeira, D; Marques, CBackground Subjects with obesity exhibit changes in gut microbiota composition and function (i.e. dysbiosis) that contribute to metabolic dysfunction, including appetite impairment. Although bariatric surgery is an effective treatment for obesity with a great impact on weight loss, some subjects show weight regain due to increased energy intake after the surgery. This surgery involves gut microbiota changes tha...
Human Microbiota and Immunotherapy in Breast Cancer - A Review of Recent Develo...
Vitorino, M; Baptista de Almeida, S; Alpuim Costa, D; Faria, A; Calhau, C; Azambuja Braga, SBreast cancer (BC) is the most common malignancy and the second cause of cancer-specific death in women from high-income countries. Infectious agents are the third most important risk factor for cancer incidence after tobacco and obesity. Dysbiosis emerged as a key player that may influence cancer development, treatment, and prognosis through diverse biological processes. Metastatic BC has a highly variable cli...
Noncompliance to iodine supplementation recommendation is a risk factor for iod...
Matta Coelho, CM; Guimaraes, J; Bracchi, I; Xavier Moreira, NX; Pinheiro, C; Ferreira, P; Pestana, D; Barreiros Mota, IB; Cortez, A; Prucha, CPurpose After a recommendation for iodine supplementation in pregnancy has been issued in 2013 in Portugal, there were no studies covering iodine status in pregnancy in the country. The aim of this study was to assess iodine status in pregnant women in Porto region and its association with iodine supplementation. Methods A cross-sectional study was conducted at Centro Hospitalar Universitário São João, Porto, f...
Association between Elevated Iodine Intake and IQ among School Children in Port...
Carvalho, IP; Peixoto, B; Caldas, JC; Costa, A; Silva, S; Moreira, B; Almeida, A; Moreira-Rosário, A; Guerra, A; Delerue-Matos, C; Sintra, D; Pestana, DThe goal of this work was to examine whether elevated iodine intake was associated with adverse effects on IQ among school-age children in Portugal. In a representative sample of children from the north of the country, IQ percentiles by age (assessed with Raven’s Colored Progressive Matrices) were dichotomized to <50 (“below-average” IQs) and ≥50. Morning urine iodine concentrations, corrected for creatinine, w...
Influence of Human Milk on Very Preterms' Gut Microbiota and Alkaline Phosphata...
Morais, J; Marques, C; Faria, A; Teixeira, D; Barreiros-Mota, I; Durão, C; Araújo, J; Ismael, S; Brito, S; Cardoso, M; Macedo, I; Pereira, E; Tomé, TThe FEEDMI Study (NCT03663556) evaluated the influence of infant feeding (mother's own milk (MOM), donor human milk (DHM) and formula) on the fecal microbiota composition and alkaline phosphatase (ALP) activity in extremely and very preterm infants (≤32 gestational weeks). In this observational study, preterm infants were recruited within the first 24 h after birth. Meconium and fecal samples were collected at ...