20 documents found, page 1 of 2
Immune and spermatogenesis-related loci are involved in the development of extr...
Cerván-Martín, Miriam; Tüttelmann, Frank; Lopes, Alexandra M.; Bossini-Castillo, Lara; Rivera-Egea, Rocío; Garrido, Nicolás; Lujan, SaturninoWe conducted a genome-wide association study in a large population of infertile men due to unexplained spermatogenic failure (SPGF). More than seven million genetic variants were analysed in 1,274 SPGF cases and 1,951 unaffected controls from two independent European cohorts. Two genomic regions were associated with the most severe histological pattern of SPGF, defined by Sertoli cell-only (SCO) phenotype, name...
Good practice recommendations for information provision for those involved in r...
Kirkman-Brown, Jackson; Calhaz-Jorge, Carlos; Dancet, Eline A F; Lundin, Kersti; Martins, Mariana; Tilleman, Kelly; Thorn, Petra; Vermeulen, NathalieStudy question: What information and support should be offered to donors, intended parents and donor-conceived people, in general and in consideration of the availability of direct-to-consumer genetic testing and matching services? Summary answer: For donors, intended parents and donor-conceived offspring, recommendations are made that cover information needs and informed consent, psychosocial implications and ...
Wells and Geneva decision rules to predict pulmonary embolism: can we use them ...
Silva, B. V.; Calhaz-Jorge, Carlos; Rigueira, Joana; Rodrigues, Tiago; Silverio Antonio, P.; Morais, Pedro; Pereira, S.; Alves Da Silva, P.; Brito, J.Pulmonary embolism (PE) is a recognized complication of SARS-COV2 infection due to hypercoagulability. Before the COVID era, the need for computed tomography pulmonary angiography (CTPA) to rule out PE was determined by clinical probability, based on Wells and Geneva scores, in association with D-dimer measurements. However, patients with SARS-COV2 infection have a pro-thrombotic and pro-inflammatory state whic...
ART in Europe, 2017: results generated from European registries by ESHRE
Gliozheni, Orion; Hambartsoumian, Eduard; Strohmer, Heinz; Kreuz-Kinderwunschzentrum, Obruca & Strohmer Partnerschaft Goldenes; Petrovskaya, ElenaStudy question: What are the data on ART and IUI cycles, and fertility preservation (FP) interventions reported in 2017 as compared to previous years, as well as the main trends over the years? Summary answer: The 21st ESHRE report on ART and IUI shows the continual increase in reported treatment cycle numbers in Europe, with a decrease in the proportion of transfers with more than one embryo causing an additio...
Intronic variation of the SOHLH2 gene confers risk to male reproductive impairment
Cerván-Martín, Miriam; Suazo-Sánchez, M. Irene; Rivera-Egea, Rocío; Garrido, Nicolás; Luján, Saturnino; Romeu, Gema; Santos-Ribeiro, SamuelObjective: To evaluate whether SOHLH2 intronic variation contributes to the genetic predisposition to male infertility traits, including severe oligospermia (SO) and different nonobstructive azoospermia (NOA) clinical phenotypes. Design: Genetic association study. Setting: Not applicable. Patient(s): Five hundred five cases (455 infertile patients diagnosed with NOA and 50 with SO) and 1,050 healthy controls fr...
One stent versus two stents for distal LM PCI: insights from the experience of ...
Santos, R.; Menezes, Miguel Nobre; Carrilho-Ferreira, Pedro; Calhaz-Jorge, Carlos; Francisco, A. R.; Oliveira, Eduardo Infante de; Duarte, J.Distal left main (LM) PCIremains a challenge. One of the most debated issues is whether to use a single vs 2 stent provisional strategy. While most studies and guidelines favour a single stent strategy, the recent DK-CRUSH V trial has shown better results with a 2 stent strategy.
20 years of the European IVF-monitoring Consortium registry : what have we lear...
De Geyter, Ch.; Wyns, C.; Calhaz-Jorge, Carlos; de Mouzon, J.; Ferraretti, A. P.; Kupka, M.; Nyboe Andersen, A.; Nygren, K. G.; Goossens, V.Study question: How has the performance of the European regional register of the European IVF-monitoring Consortium (EIM)/European Society of Human Reproduction and Embryology (ESHRE) evolved from 1997 to 2016, as compared to the register of the Centres for Disease Control and Prevention (CDC) of the USA and the Australia and New Zealand Assisted Reproduction Database (ANZARD)? Summary answer: It was found that...
Isolated Non-16/18 High-Risk Human Papillomavirus Cervical Infection: Re-Evalua...
Vargas, Sara; Valente, Maria Pulido; Almeida, Margarida Mendes de; Neves, Joaquim; Calhaz-Jorge, CarlosIntroduction: High-risk human papillomavirus cervical infection is currently a well-established cause of cervical cancer. However, only a few women with persistent infections will develop cervical precancerous and malignant lesions. Approximately 20% of all cervical cancers are attributable to non-16/18 serotypes. This study aims to evaluate the results of our clinical approach to women with this infection.Mate...
Short and Long-Term Efficacy of Laparoscopic Ovarian Diathermy in Women with Po...
Luz, Rita; Barros, Joana; Aguiar, Ana; Rodrigues, Cátia; Soares, Ana Paula; Nunes, Joaquim; Sousa, Sandra; Calhaz-Jorge, CarlosIntroduction: Polycystic ovary syndrome is the most frequent cause of anovulatory infertility and management involves a multistep approach. Laparoscopic ovarian diathermy is accepted as a second-line treatment of patients who failed to respond to clomiphene citrate. The aims of this study were to determine the efficacy of this technique at short and long-term and to perform an analysis of predictive factors of ...
Validation of the Portuguese Version of EHP-30 (The Endometriosis Health Profil...
Nogueira-Silva, Cristina; Costa, Patrício; Martins, Carla; Barata, Sónia; Alho, Conceição; Calhaz-Jorge, Carlos; Osório, FilipaIntroduction: Endometriosis Health Profile Questionnaire-30 is currently the most used questionnaire for quality of life measurement in women with endometriosis. The aim of this study is to evaluate the psychometric properties and to validate the Portuguese Endometriosis Health Profile Questionnaire-30 version.Material and Methods: A sequential sample of 152 patients with endometriosis, followed in a Portugal r...