7 documents found, page 1 of 1
Practical and Multidisciplinary Review on Wilson Disease: The Portuguese Perspe...
Calinas, Filipe; Cardoso, Hélder; Carvalhana, Sofia; Ferreira, José; Gonçalves, Cristina; Magalhães, Marina; Miranda, Helena Pessegueiro; Presa, JoséWilson disease (WD) is a genetic disorder of copper metabolism caused by mutations in the ATP7B gene resulting in toxic copper accumulation in several organs. WD can manifest as liver disease, a progressive neurological disorder, a psychiatric illness, or a combination of these. Other clinical manifestations can also occur. Diagnosis is challenging and typically requires a range of biochemical tests, imaging, g...
COVID-19 Vaccination in Liver Cirrhosis: Safety and Immune and Clinical Responses.
Canha, Inês; Silva, Mário Jorge; Silva, Maria Azevedo; Sarmento Costa, Mara; Saraiva, Rita Ornelas; Ruge, André; Machado, Mariana VerdelhoIntroduction: Three years after the beginning of the SARS-CoV-2 pandemic, the safety and efficacy of COVID-19 vaccination in liver cirrhosis (LC) patients remain controversial. We aimed to study the safety, immunological, and clinical responses of LC patients to COVID-19 vaccination. Methods: Prospective multicentric study in adults with LC eligible for COVID-19 vaccination, without prior known infection. Patie...
Predictors for incomplete response to ursodeoxycholic acid in primary biliary c...
Cortez-Pinto, Helena; Liberal, Rodrigo; Lopes, Susana; Machado, Mariana; Carvalho, Joana; Dias, Teresa; Santos, Arsénio; Agostinho, CláudiaBackground: The current standard of treatment in primary biliary cholangitis (PBC) is ursodeoxycholic acid (UDCA), although a considerable proportion of patients show incomplete response resulting in disease progression. Objective: This study aimed to assess the prevalence of incomplete response to UDCA and determine associated patients' characteristics. Methods: Patients with PBC as main diagnosis were include...
Burden of liver cirrhosis in Portugal between 2010 and 2017
Silva, João Manuel; Silva, Mário Jorge; Calinas, Filipe; Nogueira, Paulo JorgeIntroduction: Liver cirrhosis is a prevalent disease in Portugal. Recent changes in alcohol consumption, as well as the wide use of direct-acting antivirals for hepatitis C since 2015, may be contributing to changes in the national burden of liver cirrhosis in the last few years. Objectives: We aim to characterize the burden of cirrhosis in Portugal between 2010 and 2017. Patients and methods: We analyzed all h...
Gynecological history up to diagnosis and pregnancy outcomes in diagnosed Wilso...
Roseira, Joana; Lopes, Rita; Silva, Mário Jorge; Vieira, Ana Margarida; Sampaio, Margarida; Calinas, FilipeIntroduction: most studies narrowly focus on pregnancy outcome comparisons between Wilson's disease (WD) patients on and off treatment. We aimed to identify menses irregularities in untreated WD, and to evaluate pregnancy outcomes in treated WD patients as compared to matched controls (with and without liver disease). Methods: females with WD, hepatitis C (liver disease controls), and other gastrointestinal con...
Ten years of hospital admissions for liver cirrhosis in Portugal
Silva, Mário J.; Rosa, Matilde V.; Nogueira, Paulo; Calinas, FilipeBackground and aims More data on epidemiology of liver diseases in Europe are needed. We aimed to characterize hospital admissions for liver cirrhosis in Portugal during the past decade. Patients and methods We analyzed all hospital admissions for cirrhosis in Portugal Mainland between 2003 and 2012 registered in the national Diagnosis-Related Group database. Cirrhosis was classified according to etiology consi...
Treatment of HBV HCV co-infection: exceeded response.
Barbosa, João; Calinas, FilipeHepatitis B (HBV) and hepatitis C (HCV) are the most common causes of chronic liver disease. Due to shared routes of transmission, co-infection with HBV and HCV is not uncommon. Higher rates of cirrhosis and hepatocelular carcinoma have been demonstrated in HBV/HCV co-infected patients. No treatment standard has been established for HBV/HCV co-infected patients. Treatment decisions must be made based upon ident...