3 documents found, page 1 of 1
A novel 4-aminoquinoline chemotype with multistage antimalarial activity and la...
Ferreira, Letícia Tiburcio; Cassiano, Gustavo Capatti; Alvarez, Luis Carlos Salazar; Okombo, John; Calit, Juliana; Fontinha, Diana; Gil-Iturbe, EvaFunding Information: This study was supported by Fundação de Amparo à Pesquisa do Estado de São Paulo - FAPESP (2019/02171-3 and 2021/13809-9 to LTF, 2017/18611-7 to FTMC, 2021/06769-0 to DYB, and 2018/24878-9 to JC), Conselho Nacional de Desenvolvimento Científico e Tecnológico – CNPq (441038/2020-4 and 440373/2022-0 to CHA, and 162117/2018-3 to LCSA), and the National Institutes of Health – NIH (R01 AI124678 ...
Innovative Multistage ML-QSAR Models for Malaria
Borba, Joyce V. B.; Salazar-Alvarez, Luis Carlos; Ferreira, Letícia Tiburcio; Silva-Mendonça, Sabrina; Silva, Meryck Felipe Brito da; Sanches, Igor H.Funding Information: The Article Processing Charge for the publication of this research was funded by the Coordination for the Improvement of Higher Education Personnel - CAPES (ROR identifier: 00x0ma614). The authors would like to thank the funding agencies CNPq (441038/2020-4), CAPES-STINT (88881.304811/2018-01), FAPEG (202010267000272), FAPESP (Grants 2017/18611-7, 2021/06769-0, and 2021/06769-0), Instituto ...
QSAR-driven design and discovery of novel compounds with antiplasmodial and tra...
Lima, Marilia N.N.; Melo-Filho, Cleber C.; Cassiano, Gustavo C.; Neves, Bruno J.; Alves, Vinicius M.; Braga, Rodolpho C.; Cravo, Pedro V.L.Malaria is a life-threatening infectious disease caused by parasites of the genus Plasmodium, affecting more than 200 million people worldwide every year and leading to about a half million deaths. Malaria parasites of humans have evolved resistance to all current antimalarial drugs, urging for the discovery of new effective compounds. Given that the inhibition of deoxyuridine triphosphatase of Plasmodium falci...