3 documents found, page 1 of 1
Molecular and cognitive signatures of ageing partially restored through synthet...
Lemaitre, P; Tareen, SH; Pasciuto, E; Mascali, L; Martirosyan, A; Callaerts-Vegh, Z; Poovathingal, S; Dooley, J; Holt, MG; Yshii, L; Liston, ACognitive decline is a common pathological outcome during aging, with an ill-defined molecular and cellular basis. In recent years, the concept of inflammaging, defined as a low-grade inflammation increasing with age, has emerged. Infiltrating T cells accumulate in the brain with age and may contribute to the amplification of inflammatory cascades and disruptions to the neurogenic niche observed with age. Recen...
Astrocyte-targeted gene delivery of interleukin 2 specifically increases brain-...
Yshii, L; Pasciuto, E; Bielefeld, P; Mascali, L; Lemaitre, P; Marino, M; Dooley, J; Kouser, L; Verschoren, S; Lagou, V; Kemps, H; Gervois, P; Boer, AThe ability of immune-modulating biologics to prevent and reverse pathology has transformed recent clinical practice. Full utility in the neuroinflammation space, however, requires identification of both effective targets for local immune modulation and a delivery system capable of crossing the blood-brain barrier. The recent identification and characterization of a small population of regulatory T (Treg) cells...
AAV-mediated delivery of an anti-BACE1 VHH alleviates pathology in an Alzheimer...
Marino, M; Zhou, L; Rincon, MY; Callaerts-Vegh, Z; Verhaert, J; Wahis, J; Creemers, E; Yshii, L; Wierda, K; Saito, T; Marneffe, C; Voytyuk, ISingle domain antibodies (VHHs) are potentially disruptive therapeutics, with important biological value for treatment of several diseases, including neurological disorders. However, VHHs have not been widely used in the central nervous system (CNS), largely because of their restricted blood-brain barrier (BBB) penetration. Here, we propose a gene transfer strategy based on BBB-crossing adeno-associated virus (...