4 documents found, page 1 of 1
Sodium intake by hyperosmotic rats treated with a GABAA receptor agonist into t...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Colombari, Débora Simões de Almeida; Luca Junior, L. A. de; Menani, José VanderleiInhibitory mechanisms in the lateral parabrachial nucleus (LPBN) and central GABAergic mechanisms are involved in the regulation of water and NaCl intake. Besides increasing fluid depletion-induced sodium intake, the activation of GABAA receptors with muscimol into the LPBN also induces ingestion of 0.3 M NaCl in normonatremic, euhydrated rats. It has been suggested that inhibitory mechanisms activated by osmot...
Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chlori...
Kimura, Everton Heidi; Oliveira, Lisandra Brandino de; Menani, José Vanderlei; Callera, João CarlosBackground: Activation of GABAB receptors with baclofen into the lateral parabrachial nucleus (LPBN) induces ingestion of water and 0.3 M NaCl in fluid replete rats. However, up to now, no study has investigated the effects of baclofen injected alone or combined with GABAB receptor antagonist into the LPBN on water and 0.3 M NaCl intake in rats with increased plasma osmolarity (rats treated with an intragastric...
Baclofen into the lateral parabrachial nucleus induces hypertonic sodium chlori...
Oliveira, Lisandra Brandino de; Kimura, Everton Heidi; Callera, João Carlos; Luca Junior, L. A. de; Colombari, Débora Simões de AlmeidaGABAA and GABAB receptors are present in the lateral parabrachial nucleus (LPBN), a pontine area involved with inhibitory mechanisms related to the control of sodium appetite. Activation of GABAA receptors in the LPBN induces strong ingestion of 0.3 M sodium chloride (NaCl) in normonatremic and euhydrated rats. In the present study, we investigated the effects of the GABAB receptor agonist baclofen, injected al...
GABAergic mechanisms of the lateral parabrachial nucleus on sodium appetite.
Oliveira, Lisandra Brandino de; Callera, João Carlos; Luca Junior, L. A. de; Colombari, Débora Simões de Almeida; Menani, José VanderleiGABAergic activation in the lateral parabrachial nucleus (LPBN) induces sodium and water intake in satiated and normovolemic rats. In the present study we investigated the effects of GABAA receptor activation in the LPBN on 0.3M NaCl, water, 2% sucrose and food intake in rats submitted to sodium depletion (treatment with the diuretic furosemide subcutaneously + sodium deficient food for 24 h), 24 h food depriva...