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Development of topical eye-drops of lactoferrin-loaded biodegradable nanopartic...
López-Machado, Ana; Díaz, Natalia; Cano, Amanda; Espina, Marta; Badía, Josefa; Baldomà, Laura; Calpena, Ana Cristina; Biancardi, MartinaOcular inflammation is one of the most common comorbidities associated to ophthalmic surgeries and disorders. Since conventional topical ophthalmic treatments present disadvantages such as low bioavailability and relevant side effects, natural alternatives constitute an unmet medical need. In this sense, lactoferrin, a high molecular weight protein, is a promising alternative against inflammation. However, lact...
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocul...
Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana CristinaOcular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradab...
Memantine loaded PLGA PEGylated nanoparticles for Alzheimer's disease: in vitro...
Sánchez-López, Elena; Ettcheto, Miren; Egea, Maria Antonia; Espina, Marta; Cano, Amanda; Calpena, Ana Cristina; Camins, Antoni; Carmona, NuriaBackground: Memantine, drug approved for moderate to severe Alzheimer’s disease, has not shown to be fully effective. In order to solve this issue, polylactic-co-glycolic (PLGA) nanoparticles could be a suitable solution to increase drug’s action on the target site as well as decrease adverse effects. For these reason, Memantine was loaded in biodegradable PLGA nanoparticles, produced by double emulsion method ...