2 documents found, page 1 of 1
Characterization of novel double-reporter strains of Mycobacterium abscessus fo...
Bento, CM; Calster, K; Piller, T; Oliveira, GS; Vooght, L; Cappoen, D; Cos, P; Gomes, MS; Silva, TMycobacterium abscessus (Mab) is an emerging pathogen that poses a severe health threat, especially in people with cystic fibrosis and other chronic lung diseases. Available drugs are largely ineffective due to an exquisite intrinsic resistance, making Mab infections only comparable to multidrug-resistant tuberculosis. Current treatment is based on lengthy multidrug therapy, complicated by poor outcomes and hig...
Assay Development for High-Throughput Drug Screening Against Mycobacteria
Oliveira, GS; Bento, CM; Pombinho, A; Reis, R; Calster, K; Vooght, L; Maia, AF; Cos, P; Gomes, MS; Silva, TMycobacterium abscessus (Mab) infections are challenging to treat due to high intrinsic drug resistance, comparable to multidrug-resistant tuberculosis. Treatments are extremely ineffective and based on a multi-drug regimen, resulting in low patient compliance. Consequently, the scientific community is urged to identify new and effective drugs to treat these infections. One of the strategies employed to this en...