52 documents found, page 1 of 6
Structural findings obtained through Optic Coherence Tomography and Magnetic Re...
Camacho, Pedro; Camacho, PedroIntroduction: Optical coherence tomography (OCT) is essential in evaluating glaucomatous optic neuropathy (GON), particularly in asymptomatic stages, by analyzing retinal ganglion cells (RGCs) and retinal nerve fiber layers (RNFL). However, the relationship between magnetic resonance imaging (MRI) findings and structural biomarkers from OCT remains unclear. Objective: To study the association between MRI and OC...
Foveal avascular zone area measurement in diabetic patients: superficial, deep ...
Pereira, Bruno; Faria, Ross; Domingues, Cátia; Barros, Ana; Varandas, Teresa; Henriques, José; Nascimento, João; Carolino, Elisabete; Camacho, PedroPurpose: To compare differences in the foveal avascular zone (FAZ) area, measured in the Superficial Vascular Complex (SVC), Deep Vascular Complex (DVC), and a combined analysis of both (SDVC), using two Spectral Domain OCT angiography (OCT-A) protocols, High Speed (HS) and High Resolution (HR). Methods: A total of 26 eyes of diabetic patients, with and without macular oedema, were examined with two different f...
DNA methyltransferase expression (DNMT1, DNMT3a, and DNMT3b) as a potential bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Rosa, Paulo Caldeira; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoBackground/Objectives: Age-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (DNMT1, DNMT3A, and DNMT3B) in AMD patients and explore divergent expression patterns across different stages of AMD. Methods: Thirty-eight AMD patients were prospe...
Neurodegeneration and choroidal vascular features on OCT in the progression to ...
Costa, Inês; Carvalho, Ana; Andrade, Helton; Pereira, Bruno; Camacho, PedroAim: To quantify and compare longitudinal thickness changes of the ganglion cell complex (GCC) and the choroid in patients with different patterns of age-related macular degeneration (AMD) progression. Methods: Retrospective cohort analysis of anonymized data from participants aged 50y or more and diagnosed with early/intermediate AMD in at least one eye (with no evidence of advanced AMD). A total of 64 partici...
Structural findings obtained through optic coherence tomography and magnetic re...
Creado, Joana; Caetano, Marco; Camacho, PedroABSTRACT - Introduction: Optical coherence tomography (OCT) is essential in evaluating glaucomatous optic neuropathy (GON), particularly in asymptomatic stages, by analyzing retinal ganglion cells (RGCs) and retinal nerve fiber layers (RNFL). However, the relationship between magnetic resonance imaging (MRI) findings and structural biomarkers from OCT remains unclear. Objective: To study the association between...
DNA Methyltransferase Expression (DNMT1, DNMT3a, and DNMT3b) as a Potential Bio...
Camacho, Pedro; Ribeiro, Edna; Pereira, Bruno; Nascimento, João; Caldeira Rosa, Paulo; Henriques, José; Barrão, Sandra; Sadio, Silvia; Quendera, BrunoAge-related macular degeneration (AMD) is a global cause of vision loss, with limited therapeutic options highlighting the need for effective biomarkers. This study aimed to characterize plasma DNA methyltransferase expression (, , and ) in AMD patients and explore divergent expression patterns across different stages of AMD. : Thirty-eight AMD patients were prospectively enrolled and stratified by disease seve...
Avaliação do endotélio corneano através de microscopia especular em participant...
Sabino, Bárbara; Pinto, Joana; Branco, Tiago; Batista, Ricardo; Pereira, Bruno; Camacho, PedroIntrodução: Apesar da integridade morfológica e funcional do endotélio corneano, essencial para a transparência corneana, ser afetada com a Diabetes Mellitus (DM) a sua relação com severidade de retinopatia diabética e presença de edema macular diabético não é clara. Objetivos: Avaliar as características morfológicas do endotélio corneano em doentes com Diabetes Mellitus Tipo 2 (DMT2) com diferentes perfis de r...
Persistence with medical glaucoma therapy in newly diagnosed patients
Menino, Joana; Camacho, Pedro; Coelho, AndréBackground: Monotherapy, age, and side effects are significant risk factors for the discontinuation of antiglaucoma therapy. Long-term therapy persistence is crucial for slowing disease progression and preventing irreversible blindness. Therefore, it is essential to identify patients at higher risk of discontinuation. In this study, we aimed to evaluate the real-world persistence of antiglaucoma therapy in pati...
Off-label use of bevacizumab in patients diagnosed with age-related macular deg...
Estarreja, João; Mendes, Priscila; Silva, Carina; Camacho, Pedro; Mateus, VanessaBackground: Age-related macular degeneration (AMD) is the leading cause of vision loss in elderly people. Current pharmacological treatment in vascular AMD includes anti-VEGF agents, such as ranibizumab and aflibercept. Additionally, the off-label use of bevacizumab has been shown to be effective and has a lower cost, making it an interesting pharmacological approach; however, there is no consensus about its us...
Avaliação da adesão à terapêutica em doentes com diabetes tipo 2 e hipertensão ...
Rosu, Amalia; Coelho, André; Camacho, PedroObjetivos: Avaliação da adesão à terapêutica em doentes recém-diagnosticados com Diabetes Mellitus tipo 2 e Hipertensão Arterial, nos Cuidados de Saúde Primários na Região Lisboa Vale Tejo. Metodologia: Estudo observacional de coorte retrospetivo. População composta pelos doentes recém-diagnosticados com Diabetes Mellitus tipo 2 e Hipertensão Arterial, em início de tratamento. Os dados foram extraídos do Sistem...