2 documents found, page 1 of 1
Synthesis and cytotoxic evaluation of a series of 2-amino-naphthoquinones again...
Moraes, Thiago A. P. de; S. Filha, Maria J.; Camara, Celso A.; Silva, Tania M. S.; Soares, Bruno M.; Bomfim, Igor S.; Pessoa, ClaudiaThe cytotoxicity of a series of aminonaphthoquinones resulting from the reaction of suitable aminoacids with 1,4-naphthoquinone was assayed against SF-295 (glioblastoma), MDAMB-435 (breast), HCT-8 (colon), HCT-116 (colon), HL-60 (leukemia), OVCAR-8 (ovarian), NCI-H358M (bronchoalveolar lung carcinoma) and PC3-M (prostate) cancer cells and also against PBMC (peripheral blood mononuclear cells). The results demon...
Synthesis of 2,3-Diyne-1,4-naphthoquinone derivatives and evaluation of cytotox...
Silva, Mauro G.; Camara, Celso A.; Silva, Tania M. S.; Feitosa, Anderson C. S.; Meira, Assuero S.; Pessoa, CláudiaA series of 2,3-diyne-1,4-naphthoquinone derivatives was synthesized from 2,3-dibromo- 1,4-naphthoquinone and various functionalized terminal alkynes using palladium-catalyzed Sonogashira cross-coupling reaction. The diynes were evaluated as potential cytotoxic agents against three tumor cell lines: human ovarian adenocarcinoma (OVCAR-8), human metastatic prostate cancer (PC-3M) and human bronchoalveolar lung c...