SUMMARY OBJECTIVE Children with renal tumors included in clinical trials have significantly better outcomes. In Brasil, the enrollment of patients in clinical trials remains challenging. Here we aimed to describe participation accrual in the Brazilian Wilms Tumor Study Group (BWTSG) and to identify barriers to trial registration of children with renal tumors. METHODS We determined the numbers of renal tumor dia...
ABSTRACT Objective: To identify delays in the health care system experienced by children and adolescents and young adults (AYA; aged 0-29 years) with osteosarcoma and Ewing sarcoma using information from the Brazilian hospital-based cancer registries. Methods: Patient data were extracted from 161 Brazilian hospital-based cancer registries between 2007 and 2011. Hospital, diagnosis, and treatment delays were ana...
SUMMARY Childhood renal tumors account for ~7% of all childhood cancers, and most cases are embryonic Wilms’ tumors (WT). Children with WT are usually treated by either COG or SIOP. The later treats the children using preoperative chemotherapy, but both have around 90% of overall survival in five years. WT is a genetically heterogeneous group with a low prevalence of known somatic alterations. Only around 30% o...
Abstract Objective: The population-based cancer registries (PBCR) and the Information System on Live Births in Brazil (Sistema de Informações sobre Nascidos Vivos [SINASC]) have information that enables the test for risk factors associated with leukemia at an early age. The aim of this study was to identify maternal and birth characteristics associated with early-age acute leukemia (EAL) in Brazil. Methods: A c...
A histiocitose de células de Langerhans pode apresentar-se de diversas formas clínicas. Neste trabalho, os autores relatam caso de menino de três anos de idade com queixa de otite média crônca e tumoração na região da mastóide direita. O exame anatomopatológico revelou histiocitose. O paciente apresentava dermatite importante no couro cabeludo e alterações distróficas com onicólise, pústulas e deformidades ungu...
OBJETIVOS: Identificar os principais sinais e sintomas do retinoblastoma e determinar o tempo médio entre o início dos sintomas e o diagnóstico. MÉTODOS: Estudo retrospectivo, com revisão dos prontuários das crianças diagnosticadas com retinoblastoma entre janeiro de 1991 e junho de 2000 no Departamento de Pediatria do Hospital do Câncer de São Paulo. Análise estatística: teste t de Student, análise e variância...
OBJETIVO: Descrever as características clínicas das crianças e adolescentes portadores de doenças oncológicas que foram admitidos na UTIP apresentando sepse grave ou choque séptico. E determinar os fatores preditores de óbito e uso de ventilação pulmonar mecânica (VPM). MÉTODOS: Foram analisadas prospectivamente 33 crianças com diagnóstico de sepse grave ou choque séptico, na UTIP do Hospital do Câncer, entre j...
Wilms' tumor is one of the most common solid tumors in children and is an interesting model for understanding the pathogenesis of embryonal tumors. Cytokeratins are intracellular fibrous proteins present in tissue of epithelial origin. The immunoexpression of the pan-cytokeratin AE1AE3 was studied in paraffin-embedded tissue sections from 24 Wilms' tumors (12 with nephrogenic rests) and also tissue samples from...
OBJETIVO: Alertar para a necessidade do conhecimento e investigação dos sinais e sintomas iniciais do câncer infantil, bem como para a responsabilidade de todos envolvidos no processo do seu diagnóstico precoce a fim de melhorar os nossos índices de cura. MÉTODOS: Revisão da literatura através de consulta ao Medline. RESULTADOS: O diagnóstico do câncer infantil é um processo complexo e muitas são as variáveis q...