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Virulence gene repression promotes Listeria monocytogenes systemic infection

Pombinho, R; Vieira, A; Camejo, A; Archambaud, C; Cossart, P; Sousa, S; Cabanes, D

The capacity of bacterial pathogens to infect their hosts depends on the tight spatiotemporal regulation of virulence genes. The Listeria monocytogenes (Lm) metal efflux pump repressor CadC is highly expressed during late infection stages, modulating lipoprotein processing and host immune response. Here we investigate the potential of CadC as broad repressor of virulence genes. We show that CadC represses the e...

Date: 2020   |   Origin: Repositório Aberto da Universidade do Porto
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Listeria monocytogenes CadC Regulates Cadmium Efflux and Fine-tunes Lipoprotein...

Pombinho, R; Camejo, A; Vieira, A; Reis, O; Carvalho, F; Almeida, MT; Pinheiro, JC; Sousa, S; Cabanes, D

Listeria monocytogenes is a major intracellular human foodborne bacterial pathogen. We previously revealed L. monocytogenes cadC as highly expressed during mouse infection. Here we show that L. monocytogenes CadC is a sequence-specific, DNA-binding and ca

Date: 2017   |   Origin: Repositório Aberto da Universidade do Porto
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