12 documents found, page 1 of 2
Licochalcone A: A Potential Multitarget Drug for Alzheimer's Disease Treatment
Olloquequi, Jordi; Ettcheto, Miren; Cano, Amanda; Fortuna, A.; Bicker, Joana; Sánchez-López, Elena; Paz, Cristian; Ureña, Jesús; Verdaguer, EsterLicochalcone A (Lico-A) is a flavonoid compound derived from the root of the Glycyrrhiza species, a plant commonly used in traditional Chinese medicine. While the Glycyrrhiza species has shown promise in treating various diseases such as cancer, obesity, and skin diseases due to its active compounds, the investigation of Licochalcone A's effects on the central nervous system and its potential application in Alz...
Biodegradable nanoparticles for the treatment of epilepsy: From current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
Lipid nanoparticles for the posterior eye segment
Bonilla, Lorena; Espina, Marta; Severino, Patricia; Cano, Amanda; Ettcheto, Miren; Camins, Antoni; García, Maria Luisa; Souto, Eliana B.This review highlights the application of lipid nanoparticles (Solid Lipid Nanoparticles, Nanostructured Lipid Carriers, or Lipid Drug Conjugates) as effective drug carriers for pathologies affecting the posterior ocular segment. Eye anatomy and the most relevant diseases affecting the posterior segment will be summarized. Moreover, preparation methods and different types and subtypes of lipid nanoparticles wil...
Biodegradable nanoparticles for the treatment of epilepsy: from current advance...
Bonilla, Lorena; Esteruelas, Gerard; Ettcheto, Miren; Espina, Marta; García, María Luisa; Camins, Antoni; Souto, Eliana B.; Cano, AmandaEpilepsy is the second most prevalent neurological disease worldwide. It is mainly characterized by an electrical abnormal activity in different brain regions. The massive entrance of Ca2+ into neurons is the main neurotoxic process that lead to cell death and finally to neurodegeneration. Although there are a huge number of antiseizure medications, there are many patients who do not respond to the treatments a...
State of the Art on Toxicological Mechanisms of Metal and Metal Oxide Nanoparti...
García-Torra, Victor; Cano, Amanda; Espina, Marta; Ettcheto, Miren; Camins, Antoni; Barroso, Emma; Vazquez-Carrera, Manel; García, Maria LuisaMetal nanoparticles have been extensively investigated for different types of pharmaceutical applications. However, their use has raised some concerns about their toxicity involving the increase of reactive oxygen species causing cellular apoptosis. Therefore, in this review we summarize the most relevant toxicity mechanisms of gold, silver, copper and copper oxide nanoparticles as well as production methods of...
Surface Functionalization of PLGA Nanoparticles to Increase Transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimer’s disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. N...
Surface functionalization of PLGA nanoparticles to increase transport across th...
Del Amo, Laura; Cano, Amanda; Ettcheto, Miren; Souto, Eliana B.; Espina, Marta; Camins, Antoni; García, Maria Luísa; Sánchez-López, ElenaAlzheimers disease (AD) is a chronic neurodegenerative disorder that accounts for about 60% of all diagnosed cases of dementia worldwide. Although there are currently several drugs marketed for its treatment, none are capable of slowing down or stopping the progression of AD. The role of the blood-brain barrier (BBB) plays a key role in the design of a successful treatment for this neurodegenerative disease. Na...
Metal-Based Nanoparticles as Antimicrobial Agents: An Overview
Sánchez-López, Elena; Gomes, Daniela; Esteruelas, Gerard; Bonilla, Lorena; Lopez-Machado, Ana Laura; Galindo, Ruth; Cano, Amanda; Espina, MartaMetal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to ...
Dexibuprofen biodegradable nanoparticles: one step closer towards a better ocul...
Sánchez-López, Elena; Esteruelas, Gerard; Ortiz, Alba; Espina, Marta; Prat, Josefina; Muñoz, Montserrat; Cano, Amanda; Calpena, Ana CristinaOcular inflammation is one of the most prevalent diseases in ophthalmology, which can affect various parts of the eye or the surrounding tissues. Non-steroidal anti-inflammatory drugs (NSAIDs) such as ibuprofen, are commonly used to treat ocular inflammation in the form of eye-drops. However, their bioavailability in ocular tissues is very low (less than 5%). Therefore, drug delivery systems such as biodegradab...
Metal-based nanoparticles as antimicrobial agents: an overview
Sánchez-López, Elena; Gomes, Daniela; Esteruelas, Gerard; Bonilla, Lorena; Lopez-Machado, Ana Laura; Galindo, Ruth; Cano, Amanda; Espina, MartaMetal-based nanoparticles have been extensively investigated for a set of biomedical applications. According to the World Health Organization, in addition to their reduced size and selectivity for bacteria, metal-based nanoparticles have also proved to be effective against pathogens listed as a priority. Metal-based nanoparticles are known to have non-specific bacterial toxicity mechanisms (they do not bind to ...