4 documents found, page 1 of 1
Image-guided nanodelivery of Pt(IV) prodrugs to GRP-receptor positive tumors
Silva, Francisco; Mendes, Carolina; D'Onofrio, Alice; Campello, Maria Paula Cabral; Marques, Fernanda; Pinheiro, Teresa; Gonçalves, KyleOver the last decades, gold nanoparticles (AuNPs) have proven to be remarkable tools for drug delivery and theranostic applications in cancer treatment. On the other hand, Pt(IV) prodrugs have been employed as an interesting alternative to the more common Pt(II) complexes, such as cisplatin, for cancer chemotherapy. Searching to design an image-guided nanocarrier to deliver selectively Pt(IV) prodrugs to tumors...
Dose rate effects on the selective radiosensitization of prostate cells by GRPR...
Marques, Ana; Belchior, Ana; Silva, Francisco; Marques, Fernanda; Campello, Maria Paula Cabral; Pinheiro, Teresa; Santos, Pedro; Santos, LuisFor a while, gold nanoparticles (AuNPs) have been recognized as potential radiosensitizers in cancer radiation therapy, mainly due to their physical properties, making them appealing for medical applications. Nevertheless, the performance of AuNPs as radiosensitizers still raises important questions that need further investigation. Searching for selective prostate (PCa) radiosensitizing agents, we studied the r...
Aptamer-Functionalized Gold Nanoparticles for Drug Delivery to Gynecological Ca...
Lopes-Nunes, Jessica; Agonia, Ana S.; Rosado, Tiago; Gallardo, Eugenia; Palmeira-de-Oliveira, Rita; Palmeira-de-Oliveira, AnaCervical cancer is one of the most common cancers and is one of the major cause of deaths in women, especially in underdeveloped countries. The patients are usually treated with surgery, radiotherapy, and chemotherapy. However, these treatments can cause several side effects and may lead to infertility. Another concerning gynecologic cancer is endometrial cancer, in which a high number of patients present a poo...
Dual Imaging Gold Nanoplatforms for Targeted Radiotheranostics
Silva, Francisco; Paulo, António; Pallier, Agnès; Même, Sandra; Tóth, Éva; Gano, Lurdes; Marques, Fernanda; Geraldes, Carlos F. G. C.Gold nanoparticles (AuNPs) are interesting for the design of new cancer theranostic tools, mainly due to their biocompatibility, easy molecular vectorization, and good biological half-life. Herein, we report a gold nanoparticle platform as a bimodal imaging probe, capable of coordinating Gd3+ for Magnetic Resonance Imaging (MRI) and 67Ga3+ for Single Photon Emission Computed Tomography (SPECT) imaging. Our AuNP...