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New metallophamaceutic reduced renal injury induced by non-steroidal anti-infla...
Macêdo,Clóvis Ney Pinheiro; Braga,Francisco Evanilso Silva; Campelo,Ana Paula Bomfim Soares; Diniz,Gabriel Maia; Lopes,Luiz Gonzaga de FrançaAbstract Purpose To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, able to modulate the histological changes caused by the NASID (meloxicam). Methods Wistar rats were assigned into three groups (n=6 rats/group): Sham group (saline solution), NSAID group (meloxicam - 15 mg/kg) and Rut-bpy group (100 mg/kg of Rut-bpy associated with 15mg/kg of meloxicam). At the end of e...
Oil mixes omega 9, 6 and 3, enriched with seaweed, promoted reduction of therma...
Campelo,Ana Paula Bomfim Soares; Campelo,Márcio Wilker Soares; Brito,Gerly Anne de Castro; Jamacaru,Francisco Vagnaldo FechinePURPOSE: To examine the effects of the oil mixes (ω-9, ω-6 and ω-3) in rats subjected to thermal burn. It was also aimed to assess whether the sources of ω3 would interfere with the effect of such mixes on the thermal injury.METHODS:Thirty-six rats distributed into five groups: burned + water, burned + isolipid mix, burned + oil mix 1 (ALA), burned + oil mix 2 (ALA + EPA + DHA of fish) and burned + oil mix 3 (A...
Preconditioning with oil mixes of high ratio Omega-9: Omega-6 and a low ratio O...
Pinheiro,Petrúcia Maria Antero; Campelo,Ana Paula Bomfim Soares; Guimarães,Sérgio Botelho; Patrocínio,Régia Maria Vidal do; Valença Junior,José TelmoPURPOSE: This study aimed to assess the effects of preconditioning with mixtures of oils containing high/low ratio of ω-6/ω-3 and ω-9/ω-6, respectively, in an experimental model of cerebral ischemia-reperfusion (I/R). METHODS: Forty-two Wistar rats were randomly distributed into two groups: control (n=24) and test (n=18). Control group was subdivided in 4 subgroups (n=6): G1: Sham-Water; G2: I/R-Water; G3: Sham...
An optimized animal model for partial and total skin thickness burns studies
Campelo,Ana Paula Bomfim Soares; Campelo,Marcio Wilker Soares; Britto,Gerly Anne de Castro; Ayala,Alejandro Pedro; Guimarães,Sergio BotelhoPURPOSE: Development of an improved animal model for studying skin burns in rats. METHODS: Twenty-four male Wistar rats were randomly assigned to four groups (n=6): G1-Control, G2- T100°C, G3-T150°C and G4-T200°C. Two 10 x 10 mm squares were outlined with a sterile surgical marker on each side and along the vertebral column using a prepared template positioned between the anterior and posterior limbs. G2-G4 rat...
Effects of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor, i...
Campelo,Marcio Wilker Soares; Campelo,Ana Paula Bomfim Soares; Lopes,Luiz Gonzaga de França; Santos,Armenio Aguiar dos; Guimarães,Sergio BotelhoPURPOSE: To evaluate the effect of Rut-bpy (Cis-[Ru(bpy)2(SO3)(NO)]PF 6), a novel nitric oxide donor in Nω-nitro-L-arginine methyl ester (L-NAME)-induced hypertensive rats. METHODS: Twenty-four male Wistar rats were randomly assigned to four groups (n=6), named according to the treatment applied (G1-Saline, G2-Rut-bpy, G3-L-NAME and G4-L-NAME+Rut-bpy). L-NAME (30 mg/Kg) was injected intraperitoneally 30 minutes...