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The anti-caspase inhibitor Q-VD-OPH prevents AIDS disease progression in SIV-in...
Laforge, Mireille; Silvestre, Ricardo Jorge Leal; Rodrigues, Vasco; Garibal, Julie; Campillo-Gimenez, Laure; Mouhamad, Shahul; Monceaux, ValérieApoptosis has been proposed as a key mechanism responsible for CD4+ T cell depletion and immune dysfunction during HIV infection. We demonstrated that Q-VD-OPH, a caspase inhibitor, inhibits spontaneous and activation-induced death of T cells from SIV-infected rhesus macaques (RMs). When administered during the acute phase of infection, Q-VD-OPH was associated with (a) reduced levels of T cell death, (b) preser...
Date: 2018
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Origin: RepositóriUM - Universidade do Minho