Made available in DSpace on 2018-12-11T17:17:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2018-01-17; Background: Increased reactive oxygen species (ROS) generation in diabetes mellitus (DM) is an important mechanism leading to diabetic cardiomyopathy. Apocynin, a drug isolated from the herb Picrorhiza kurroa, is considered an antioxidant agent by inhibiting NADPH oxidase activity and improving ROS scav...
Made available in DSpace on 2018-12-11T17:04:51Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-11-01; Aldosterone plays a pivotal role in the pathophysiology of systolic heart failure. However, whether early aldosterone antagonism improves cardiac remodeling during persistent pressure overload is unsettled. We evaluated the effects of aldosterone antagonist spironolactone on cardiac remodeling in rats w...
Made available in DSpace on 2018-12-11T17:05:27Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-09-01; Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP); Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES); Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Purpose: Although increased oxidative stress is a major component of diabetic hypertensive cardiomyopa...