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Impact of splenic artery ligation after major hepatectomy on liver function, re...

Carrapita, Jorge; Abrantes, Ana Margarida; Campelos, Sofia; Gonçalves, Ana Cristina; Cardoso, Dulce; Ribeiro, Ana Bela Sarmento; Rocha, Clara

It was reported that prevention of acute portal overpressure in small-for-size livers by inflow modulation results in a better postoperative outcome. The aim is to investigate the impact of portal blood flow reduction by splenic artery ligation after major hepatectomy in a murine model. Forty-eight rats were subjected to an 85% hepatectomy or 85% hepatectomy and splenic artery ligation. Both groups were evaluat...


Study of hepatocellular function in the murine model following hepatic artery s...

Tralhão, José Guilherme; Abrantes, Ana M.; Gonçalves, Ana Cristina; Hoti, Emir; Laranjo, Mafalda; Martins, Ricardo Jorge Teixeira; Oliveiros, Bárbara

PURPOSE: To investigate the impact of selective hepatic artery clamping (SHAC) in hepatocellular function. METHODS: Three groups of Wistar male rats were subjected to SHAC ischemia period of 60min: Group A continuous SHAC were subjected to SHAC ischemia period of 60min, Group B intermittent SHAC of 30min with 5min of reperfusion and Group C intermittent SHAC of 15min with 5min of reperfusion. Animals without SH...


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