13 documents found, page 1 of 2
Modified drug delivery systems for veterinary use: pharmaceutical development a...
Souto, Eliana B.; Barbosa, Catarina I.; Baldim, Iara; Campos, Joana R.; Fernandes, Ana R.; Mazzola, Priscila G.; Andreani, Tatiana; Dias, Isabel R.Scientific research in the field of veterinary pharmacology has provided new opportunities for the development of modified release dosage forms, with the aim to improve therapeutic efficacy and reduce animal stress. The formulation of classical drug molecules with advanced biomaterials has become a new approach to increasing drug bioavailability and improving the therapeutic outcome. The main reasons for the de...
Diabetic Retinopathy and Ocular Melanoma: How Far We Are?
Souto, Eliana B.; Campos, Joana R.; Ana, Raquel da; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...
Retinal drug delivery: rethinking outcomes for the efficient replication of ret...
Souto, Eliana B.; Sanchez-Lopez, Elena; Campos, Joana R.; da Ana, Raquel; Espina, Marta; Garcia, Maria L.; Severino, Patrícia; Batain, FernandoThe retina is a highly organized structure that is considered to be "an approachable part of the brain." It is attracting the interest of development scientists, as it provides a model neurovascular system. Over the last few years, we have been witnessing significant development in the knowledge of the mechanisms that induce the shape of the retinal vascular system, as well as knowledge of disease processes tha...
Multiple cell signalling pathways of human proinsulin c-peptide in vasculopathy...
Souto, Selma B.; Campos, Joana R.; Fangueiro, Joana F.; Silva, Amélia M.; Cicero, Nicola; Lucarini, Massimo; Durazzo, Alessandra; Santini, AntonelloA major hallmark of diabetes is a constant high blood glucose level (hyperglycaemia), resulting in endothelial dysfunction. Transient or prolonged hyperglycemia can cause diabetic vasculopathy, a secondary systemic damage. C-Peptide is a product of cleavage of proinsulin by a serine protease that occurs within the pancreatic -cells, being secreted in similar amounts as insulin. The biological activity of human ...
Ocular cell lines and genotoxicity assessment
Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Martins-Gomes, Carlos; Silva, Améia M.; Souto, Selma B.; Lucarini, Massimo; Durazzo, AlessandraGenotoxicity screening tests aim to evaluate if and to what extent a compound in contact with the human body (e.g., a drug molecule, a compound from the environment) interacts with DNA. The comet assay is a sensitive method used to predict the risk of DNA damage in individual cells, as it quantifies the tape breaks, being the alkaline version (pH > 13) the most commonly used in the laboratory. Epithelial cells ...
Diabetic retinopathy and ocular melanoma: how far we are?
Souto, Eliana B.; Campos, Joana R.; Da Ana, Raquel; Fangueiro, Joana F.; Martins-Gomes, Carlos; Durazzo, Alessandra; Lucarini, MassimoDiabetic retinopathy causes vascular damage to retinal neurons, presenting characteristics of chronic inflammation. The development of new therapies capable of combating vision loss involves knowledge of inflammatory retinal changes. Studies in animal models and patients with diabetes have shown a high expression of the inflammatory molecules that are involved in the progression of diabetic retinopathy. Uveal m...
Linseed essential oil - source of lipids as active ingredients for pharmaceutic...
Campos, Joana R.; Severino, Patricia; Ferreira, Classius S.; Zielinska, Aleksandra; Santini, Antonello; Souto, Selma B.; Souto, Eliana B.Linseed - also known as flaxseed - is known for its beneficial effects on animal health attributed to its composition. Linseed comprises linoleic and ?-linolenic fatty acids, various dietary fibers and lignans, which are beneficial to health because they reduce the risk of cardiovascular diseases, as well as cancer, decreasing the levels of cholesterol and relaxing the smooth muscle cells in arteries increasing...
Optimization of nimesulide-loaded solid lipid nanoparticles (SLN) by factorial ...
Campos, Joana R.; Fernandes, Ana R.; Sousa, Raquel; Fangueiro, Joana F.; Boonme, Prapaporn; Garcia, Maria Luisa; Silva, Amelia M.; Naveros, Beatriz C.The aim of this work is development of a nontoxic, long-term stable solid lipid nanoparticles (SLN) formulation for the loading of Nimesulide (NiM) by a 22 factorial design. The optimized formulation was composed of 10wt% of glyceryl behenate and 2.5wt% of poloxamer 188. Immediately after production, Z-Ave of NiM-SLN was 166.1±0.114nm, with a polydispersity index (PI) of 0.171±0051 and zeta potential nearly neu...
Chapter 2 - Polyphenols for skin cancer: Chemical properties, structure-related...
Souto, Eliana B.; Sampaio, Ana C.; Campos, Joana R.; Martins-Gomes, Carlos; Aires, Alfredo; Amélia M. SilvaPolyphenols are widely spread in the plant kingdom as products of secondary metabolism. They are known for a series of biological properties that influence human health, and evidence exists that people can benefit from plant phenolics obtained either from diet or through skin application, because they can alleviate symptoms and inhibit the development of various skin disorders. The biosynthesis of polyphenols d...
Myasthenia gravis: State of the art and new therapeutic strategies
Souto, Eliana B.; Lima, Bernado; Campos, Joana R.; Martins-Gomes, Carlos; Souto, Selma B.; Silva, Amélia M.Myasthenia Gravis (MG) an autoimmune neuromuscular disease is known by the production of autoantibodies against components of the neuromuscular junction mainly to the acetylcholine receptor, which cause the destruction and compromises the synaptic transmission. This disease is characterized by fluctuating and fatigable muscle weakness, becoming more intensive with activity, but with an improvement under resting...