4 documents found, page 1 of 1
Neurodifferentiation and neuroprotection potential of mesenchymal stromal cell-...
Marques, Cláudia Raquel; Fuzeta, Miguel de Almeida; Cunha, Raquel Medina dos Santos; Pereira-Sousa, Joana; Silva, Deolinda; Campos, Jonas OliveiraParkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta, leading to a loss of DA in the basal ganglia. The presence of aggregates of alpha-synuclein (α-synuclein) is seen as the main contributor to the pathogenesis and progression of PD. Evidence suggests that the secretome of mesenc...
Pre-clinical assessment of Roflumilast therapy in a thoracic model of spinal co...
Sousa, Carla S.; Lima, Rui Augusto Ribeiro; Cibrão, Jorge R.; Gomes, Eduardo D.; Fernandes, Luís S.; Pinho, Tiffany Santos; Silva, DeolindaThe failure of axons to regenerate after a spinal cord injury (SCI) remains one of the greatest challenges in neuroscience. The initial mechanical trauma is followed by a secondary injury cascade, creating a hostile microenvironment, which not only is not permissive to regeneration but also leads to further damage. One of the most promising approaches for promoting axonal regeneration is to maintain the levels ...
Cerebral malaria model applying human brain organoids
Pedrosa, Ana Rita Silva; Campos, Jonas Oliveira; Fernandes, Aline Marie; Silva, Miguel; Calçada, Carla Sofia Martins; Marote, Ana Maria Franco AveiroNeural injuries in cerebral malaria patients are a significant cause of morbidity and mortality. Nevertheless, a comprehensive research approach to study this issue is lacking, so herein we propose an in vitro system to study human cerebral malaria using cellular approaches. Our first goal was to establish a cellular system to identify the molecular alterations in human brain vasculature cells that resemble the...
Unilateral intrastriatal 6-hydroxydopamine lesion in mice: a closer look into n...
Pinheiro, Bárbara Filipa Mendes; Cunha, Carina Isabel Soares; Marote, Ana Maria Franco Aveiro; Loureiro-Campos, Eduardo; Campos, Jonas OliveiraParkinson’s disease (PD) is a prevalent movement disorder characterized by the progressive loss of dopaminergic neurons in substantia nigra pars compacta (SNpc). The 6-hydroxydopamine (6-OHDA) lesion is still one of the most widely used techniques for modeling Parkinson’s disease (PD) in rodents. Despite commonly used in rats, it can be challenging to reproduce a similar lesion in mice. Moreover, there is a lac...