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The administration of surfactant decreased oxidative stress in lungs of mice ex...
Machado, Dafne Fernandes; Campos, Keila Karine Duarte; Silva, Natália Pereira da; Ramos, Camila de Oliveira; Cangussú, Silvia DantasThe alveolar surfactant, which composition consists of a unique and complex mixture of lipids and proteins, has immunomodulatory action. This study aimed to evaluate the effects of exogenous surfactant on pulmonary inflammatory response in mice exposed to cigarette smoke (CS). Twenty-four mice C57BL/6 were divided into four groups: control group exposed to ambient air (CG); surfactant treated group (SG); CS exp...
The exposure to formaldehyde causes renal dysfunction, inflammation and redox i...
Ramos, Camila de Oliveira; Nardeli, Clarissa Rodrigues; Campos, Keila Karine Duarte; Pena, Karina Braga; Machado, Dafne FernandesTwenty-eight Fischer male rats were divided into four groups: control group (CG), exposed to the ambient air, and groups exposed to formaldehyde (FA) at concentrations of 1% (FA1%), 5% (FA5%) and 10% (FA10%). Kidney function was assessed by dosage of uric acid, creatinine and urea. Morphometry was performed on the thickness of the lumen of Bowman's capsule and diameter of the lumen of the renal tubules. We eval...
The antioxidant and anti-inflammatory properties of lycopene in mice lungs expo...
Campos, Keila Karine Duarte; Araújo, Glaucy Rodrigues de; Martins, Thais Lourenço; Bandeira, Ana Carla Balthar; Costa, Guilherme de PaulaLycopene is a carotenoid with knownantioxidant and anti-inflammatory properties.Weaimed to evaluate the in vitro and in vivo effects of lycopene on reducing the redox imbalance and inflammation induced by cigarette smoke (CS). For the in vitro study, J774A.1 (macrophages) cells were incubated in the presence of 0.5, 1.0, 2.0, 4.0, 8.0, 10.0 and 25 μMof lycopene for 3, 6 and 24 h or in the presence of 0.1%, 0.25...
Oxidative effects on lung inflammatory response in rats exposed to different co...
Murta, Giselle Luciane; Campos, Keila Karine Duarte; Bandeira, Ana Carla Balthar; Diniz, Mirla Fiuza; Costa, Guilherme de Paula; Costa, Daniela CaldeiraThe formaldehyde (FA) is a crosslinking agent that reacts with cellular macromolecules such as proteins, nucleic acids and molecules with low molecular weight such as amino acids, and it has been linked to inflammatory processes and oxidative stress. This study aimed to analyze the oxidative effects on pulmonary inflammatory response in Fischer rats exposed to different concentrations of FA. Twenty-eight Fische...
Temporal analysis of oxidative effects on the pulmonary inflammatory response i...
Campos, Keila Karine Duarte; Manso, Rafaela Gontijo; Gonçalves, Evandro Guedes; Silva, Marcelo Eustáquio; Lima, Wanderson Geraldo deThe most common factor related to the chronic obstructive pulmonary disease (COPD) development is the chronic smoking habit. Our study describes the temporal kinesis of pulmonary cellular influx through BALF analyses of mice acutely exposed to cigarette smoke (CS), the oxidative damage and antioxidative enzyme activities. Thirty-six mice (C57BL/6, 8 weeks old, male) were divided in 6 groups: the control group (...