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New steroidal aromatase inhibitors: biological effects in hormone-dependent bre...
Sobral, Ana Filipa; Amaral, Cristina; Varela, Carla; Tavares, Elisiário; Roleira, Fernanda; Correia-Da-Silva, Georgina; Teixeira, Natércia; Campos, SaulAromatase inhibitors (AIs) are currently used as a first-line therapeutic approach for hormone-dependent (ER+) breast tumors in postmenopausal women, the most common type of cancer diagnosed among women, in which estrogen plays a key role. Aromatase is the enzyme responsible for estrogen biosynthesis, so its inhibition results in estrogen suppression, avoiding tumor growth. However, the existence of side-effect...
Date: 2016
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Origin: Revista Captar: Ciência e Ambiente para Todos