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Anti-inflammatory and antinociceptive activity of epiisopiloturine, an imidazol...

Silva, Valdelânia G.; Silva, Renan O.; Damasceno, Samara Rodrigues Bonfim; Carvalho, Nathalia S.; Prudêncio, Rafael S.; Aragão, Karoline Sabóia

The aim of this study was to investigate the antinociceptive and anti-inflammatory activities of epiisopiloturine (1), an imidazole alkaloid found in the leaves of Pilocarpus microphyllus. The anti-inflammatory activity of 1 was evaluated using several agents that induce paw edema and peritonitis in Swiss mice. Paw tissue and peritoneal fluid samples were obtained to determine myeloperoxidase (MPO) activity or ...

Date: 2014 | Origin: Oasisbr

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