18 documents found, page 1 of 2
Neuroprotection by mitochondrial NAD against glutamate-induced excitotoxicity
Paiva, Bruna S.; Neves, Diogo; Tomé, Diogo; Costa, Filipa J.; Bruno, Inês C.; Trigo, Diogo; Silva, Raquel M.; Almeida, Ramiro D.Excitotoxicity is a pathological process that occurs in many neurological diseases, such as stroke or epilepsy, and is characterized by the extracellular accumulation of high concentrations of glutamate or other excitatory amino acids (EAAs). Nicotinamide adenine dinucleotide (NAD) depletion is an early event following excitotoxicity in many in vitro and in vivo excitotoxic-related models and contributes to the...
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
Proteostasis networks in aging: novel insights from text-mining approaches
Neves, Diogo; Duarte-Pereira, Sara; Matos, Sérgio; Silva, Raquel M.Aging is a topic of paramount importance in an increasingly elderly society and has been the focus of extensive research. Protein homeostasis (proteostasis) decline is a hallmark in aging and several age-related diseases, but which specific proteins and mechanisms are involved in proteostasis (de)regulation during the aging process remain largely unknown. Here, we used different text-mining tools complemented w...
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
The role of NAD metabolism in neuronal differentiation
Neves, Diogo; Goodfellow, Brian J.; Vieira, Sandra I.; Silva, RaquelBackground: Nicotinamide adenine dinucleotide (NAD) metabolism is involved in redox and non-redox reactions that regulate several processes including differentiation of cells of different origins. Here, the role of NAD metabolism in neuronal differentiation, which remains elusive so far, was investigated. Material and methods: A protein-protein interaction network between neurotrophin signaling and NAD metaboli...
The role of NAD metabolism in neuronal differentiation
Neves, Diogo; Goodfellow, Brian J.; Vieira, Sandra I.; Silva, Raquel M.Background: Nicotinamide adenine dinucleotide (NAD) metabolism is involved in redox and non-redox reactions that regulate several processes including differentiation of cells of different origins. Here, the role of NAD metabolism in neuronal differentiation, which remains elusive so far, was investigated. Material and methods: A protein-protein interaction network between neurotrophin signaling and NAD metaboli...
Ativismo digital da causa soropositiva no Youtube: o caso do canal “João Gerald...
Neves, DiogoSubmitted by Luana Sampaio (luana.barroso@ucb.br) on 2018-06-05T12:46:29Z No. of bitstreams: 1 DiogoNevesTCCGraduacao2017.pdf: 2122553 bytes, checksum: 532d43bd2787189c0dd41e2737779106 (MD5); Approved for entry into archive by Sara Ribeiro (sara.ribeiro@ucb.br) on 2018-06-14T11:35:35Z (GMT) No. of bitstreams: 1 DiogoNevesTCCGraduacao2017.pdf: 2122553 bytes, checksum: 532d43bd2787189c0dd41e2737779106 (MD5); Made...
Mathematical model for primary production within the Portuguese coastal zone
Pinho, José L. S.; Neves, Diogo; Vieira, J.M.P.The oceanic primary production represents 40% of the Earth?s primary production. For this reason, it is admissible to state that the oceanic primary production plays a fundamental role in the global carbon cycle.
Os Valores de um Oficial de Artilharia: Passado, Presente e Futuro
Neves, DiogoNo presente Trabalho de Investigação Aplicada vamos fazer o levantamento geracional dos valores que caraterizam o Oficial de Artilharia - no Ativo, Reserva e Reforma – e aferir como se ordena, de forma valorativa, o desenvolvimento consciente dos seus valores para o exercício das suas funções de comando. O objetivo deste estudo é fazer uma abordagem integrativa dos valores da Instituição Militar em geral e dos ...