4 documents found, page 1 of 1
Phage display identified peptide with selectivity for human osteoarthritic chon...
Martins, Ivone M.; Canadas, Raphaël F.; Pereira, Hélder; Azeredo, Joana; Reis, R. L.; Oliveira, J. M.; Azevedo, Helena S.Osteoarthritis (OA) is one of the most common joint disorders in western populations, affecting millions of people worldwide and with a rising incidence as life expectancy continues to increase. Current therapies for OA management fail to halt the progressive degradation of articular cartilage, urging the need for more effective therapies to improve cartilage function and enhance patient's quality of life. Thro...
Pharmacological and non-pharmacological agents versus bovine colostrum suppleme...
Kydonaki, Eirini K.; Freitas, Laura; Reguengo, Henrique; Simón, Carlos Raposo; Bastos, Ana Raquel Fernandes; Fernandes, Emanuel MoutaOsteoporosis is defined by loss of bone mass and deteriorated bone microarchitecture. The present study compared the effects of available pharmacological and non-pharmacological agents for osteoporosis [alendronate (ALE) and concomitant supplementation of vitamin D (VD) and calcium (Ca)] with the effects of bovine colostrum (BC) supplementation in ovariectomized (OVX) and orchidectomized (ORX) rats. Seven-month...
Convection patterns gradients of non-living and living micro-entities in hydrogels
Canadas, Raphaël F.; Patricio, Pedro; Brancato, Virginia; Gasperini, Luca; Caballero, David; Pires, Ricardo A.; Costa, João; Pereira, Hélder; Yong, PingInducing thermal gradients in two injected fluid systems results in the temporal formation of mixing conductive streams. If preserved through sol-gel transition, this mechanism can be used to drive and pattern non-living and living entities in mixed hydrogels. Interfaces are vital in nature, where gradients of non-living and living entities build distinct yet continuous integrated living tissues. However, the c...
Polyhydroxyalkanoates: waste glycerol upgrade into electrospunfibrous scaffolds...
Canadas, Raphaël F.; Cavalheiro, João M.B.T.; Guerreiro, João D.T.; Almeida, M. Catarina M.D. de; Pollet, Eric; Silva, Cláudia Lobato da"This integrated study shows that waste glycerol can be bio-valorized by the fabrication of electrospun scaffolds for stem cells. Human mesenchymal stem cells (hMSC) provide an interesting model of regenerating cells because of their ability to differentiate into osteo-, chrondro-, adipo- and myogenic lineages. Moreover, hMSC have modulatory properties with potential on treatment of immunologic diseases. Electr...