6 documents found, page 1 of 1
Rasmussen’s Syndrome: Case-Series Study from a Refractory Epilepsy Reference Ce...
Serôdio, Miguel; Pires, Marcela; Azurara, Laura; Santos, Alexandra; Sá, Francisca; Silva, Rita; Canas, Nuno; Ferreira, José Carlos; Cabral, PedroIntroduction: Rasmussen’s syndrome (RS) is a rare immunomediated disease of childhood-predominant onset, presenting with refractory epilepsy and neurological deficits associated to progressive brain hemiatrophy. Its pathophysiological mechanisms are not well understood, and the effect of immunotherapy is not ascertained. Hemispheric surgery is an efficacious therapy for epilepsy, despite focal and cognitive seq...
Thyrotoxic periodic paralysis: a case report.
Vale, José; Canas, Nuno; Leal, Alberto; Vilar, HelenaThyrotoxic periodic paralysis (TPP) is characterized by recurrent episodes of muscle weakness and hypokalemia associated with thyroid hyperactivity. Reported predominantly among individuals of Asian descent, TPP is a rare manifestation of hyperthyroidism in western populations. We describe a typical case of TPP in a 33-year-old portuguese male, who presented with acute tetraparesis associated with hypokalemia (...
N170 asymmetry as an index of inferior occipital dysfunction in patients with s...
Lopes, Ricardo; Cabral, Pedro; Canas, Nuno; Breia, Paula; Foreid, John P.; Calado, Eulália; Silva, Rita; Leal, AlbertoObjective: Localizing epileptic foci in posterior brain epilepsy remains a difficult exercise in surgery for epilepsy evaluation. Neither clinical manifestations, neurological, EEG nor neuropsychological evaluations provide strong information about the area of onset, and fast spread of paroxysms often produces mixed features of occipital, temporal and parietal symptoms. We investigated the usefulness of the N17...
Post-malaria neurologic syndrome.
Matias, Gonçalo; Canas, Nuno; Antunes, Isabel; Vale, JoséThe neurologic symptoms in malaria are usually associated with a severe infection by Plasmodium falciparum. Less frequently, the presence of impaired consciousness, seizures and visual and auditory deficits is related with hypoglycemia (by malaria or quinine) or with the toxicity of anti-malarial drugs. In the last years, it was recognized a rare neurologic complication after the efficient treatment of Plasmodi...
Thyrotoxic periodic paralysis: a case report.
Vale, José; Canas, Nuno; Leal, Alberto; Vilar, HelenaThyrotoxic periodic paralysis (TPP) is characterized by recurrent episodes of muscle weakness and hypokalemia associated with thyroid hyperactivity. Reported predominantly among individuals of Asian descent, TPP is a rare manifestation of hyperthyroidism in western populations. We describe a typical case of TPP in a 33-year-old portuguese male, who presented with acute tetraparesis associated with hypokalemia (...
Brain-derived neurotrophic factor facilitates glutamate and inhibits GABA relea...
Canas, Nuno; Pereira, Inês T.; Ribeiro, Joaquim Alexandre; Sebastião, Ana MBrain-derived neurotrophic factor (BDNF) has an acute excitatory effect on rat hippocampal synaptic transmission. To compare the action of BDNF upon the release of excitatory and inhibitory neurotransmitters in the hippocampus, we studied the effect of acutely applied BDNF on the K+ -evoked glutamate and on the K+ -evoked y-aminobutyric acid (GABA) release from rat hippocampal nerve terminals (synaptosomes). Th...