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Adenosine A2A receptors format long-term depression and memory strategies in a ...

Moreira-de-Sá, Ana; Gonçalves, Francisco Q.; Lopes, João P.; Silva, Henrique B.; Tomé, Ângelo R.; Cunha, Rodrigo A.; Canas, Paula

Angelman syndrome (AS) is a neurodevelopmental disorder caused by loss of function of the maternally inherited Ube3a neuronal protein, whose main features comprise severe intellectual disabilities and motor impairments. Previous studies with the Ube3am-/p+ mouse model of AS revealed deficits in synaptic plasticity and memory. Since adenosine A2A receptors (A2AR) are powerful modulators of aberrant synaptic plas...

Date: 2020   |   Origin: Estudo Geral - Universidade de Coimbra
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