26 documents found, page 1 of 3
Downregulation of Sirtuin 1 Does Not Account for the Impaired Long-Term Potenti...
Lopes, Cátia R.; Silva, Joana S; Santos, Joana; Rodrigues, Matilde S.; Madeira, Daniela; Oliveira, Andreia; Moreira-de-Sá, Ana; Lourenço, Vanessa S.Alzheimer's disease (AD), which predominantly affects women, involves at its onset a metabolic deregulation associated with a synaptic failure. Here, we performed a behavioral, neurophysiological and neurochemical characterization of 9-month-old female APPswe/PS1dE9 (APP/PS1) mice as a model of early AD. These animals showed learning and memory deficits in the Morris water maze, increased thigmotaxis and anxiet...
Effects of Chronic Caffeine Consumption on Synaptic Function, Metabolism and Ad...
Lopes, Cátia R.; Oliveira, Andreia; Gaspar, Ingride L.; Rodrigues, Matilde S.; Santos, Joana; Szabó, Eszter; Silva, Henrique B.; Tomé, Ângelo R.Adenosine receptors mainly control synaptic function, and excessive activation of adenosine receptors may worsen the onset of many neurological disorders. Accordingly, the regular intake of moderate doses of caffeine antagonizes adenosine receptors and affords robust neuroprotection. Although caffeine intake alters brain functional connectivity and multi-omics analyses indicate that caffeine intake modifies syn...
Adenosine A2A receptors control generalization of contextual fear in rats
Simões, Ana P.; Portes, Marina A.M.; Lopes, Cátia R.; Vanz, Felipe; Lourenço, Vanessa S.; Pliássova, Anna; Gaspar, Ingride L.; Silva, Henrique B.Fear learning is essential to survival, but traumatic events may lead to abnormal fear consolidation and overgeneralization, triggering fear responses in safe environments, as occurs in post-traumatic stress disorder (PTSD). Adenosine A2A receptors (A2AR) control emotional memory and fear conditioning, but it is not known if they affect the consolidation and generalization of fear, which was now investigated. W...
Adenosine A2A Receptor Up-Regulation Pre-Dates Deficits of Synaptic Plasticity ...
Lopes, Cátia R.; Silva, Antonio C.; Silva, Henrique B.; Canas, Paula M.; Agostinho, Paula M.; Cunha, Rodrigo A.; Lopes, João PedroThe intracerebroventricular (icv) injection of amyloid peptides (Aβ) models Alzheimer's disease (AD) in mice, as typified by the onset within 15 days of deficits of memory and of hippocampal long-term potentiation (LTP) that are prevented by the blockade of adenosine A2A receptors (A2AR). Since A2AR overfunction is sufficient to trigger memory deficits, we tested if A2AR were upregulated in hippocampal synapses...
Increased ATP release and CD73-mediated adenosine A2A receptor activation media...
Augusto, Elisabete de Oliveira; Gonçalves, Francisco Q.; Real, Joana E.; Silva, Henrique B.; Pochmann, Daniela; Silva, Tiago S.; Matos, MarcoExtracellular ATP is a danger signal to the brain and contributes to neurodegeneration in animal models of Alzheimer's disease through its extracellular catabolism by CD73 to generate adenosine, bolstering the activation of adenosine A2A receptors (A2AR). Convulsive activity leads to increased ATP release, with the resulting morphological alterations being eliminated by A2AR blockade. However, it is not known i...
Adenosine A2A Receptors as Biomarkers of Brain Diseases
Moreira-de-Sá, Ana; Lourenço, Vanessa S.; Canas, Paula M.; Cunha, Rodrigo A.Extracellular adenosine is produced with increased metabolic activity or stress, acting as a paracrine signal of cellular effort. Adenosine receptors are most abundant in the brain, where adenosine acts through inhibitory A1 receptors to decrease activity/noise and through facilitatory A2A receptors (A2AR) to promote plastic changes in physiological conditions. By bolstering glutamate excitotoxicity and neuroin...
Neuronal adenosine A2A receptors signal ergogenic effects of caffeine
Aguiar, Aderbal S.; Speck, Ana Elisa; Canas, Paula M.; Cunha, Rodrigo A.Caffeine is one of the most used ergogenic aid for physical exercise and sports. However, its mechanism of action is still controversial. The adenosinergic hypothesis is promising due to the pharmacology of caffeine, a nonselective antagonist of adenosine A1 and A2A receptors. We now investigated A2AR as a possible ergogenic mechanism through pharmacological and genetic inactivation. Forty-two adult females (20...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Anandamide Effects in a Streptozotocin-Induced Alzheimer's Disease-Like Sporadi...
Moreira-Silva, Daniel; Carrettiero, Daniel C.; Oliveira, Adriele S. A.; Rodrigues, Samanta; Dos Santos-Lopes, Joyce; Canas, Paula M.; Cunha, Rodrigo A.Alzheimer's disease (AD) is characterized by multiple cognitive deficits including memory and sensorimotor gating impairments as a result of neuronal and synaptic loss. The endocannabinoid system plays an important role in these deficits but little is known about its influence on the molecular mechanism regarding phosphorylated tau (p-tau) protein accumulation - one of the hallmarks of AD -, and on the density ...
Adenosine A2A Receptors Control Glutamatergic Synaptic Plasticity in Fast Spiki...
Kerkhofs, Amber; Canas, Paula M.; Timmerman, A. J.; Heistek, Tim S.; Real, Joana I.; Xavier, Carolina; Cunha, Rodrigo A.; Mansvelder, Huibert D.Adenosine A2A receptors (A2AR) are activated upon increased synaptic activity to assist in the implementation of long-term plastic changes at synapses. While it is reported that A2AR are involved in the control of prefrontal cortex (PFC)-dependent behavior such as working memory, reversal learning and effort-based decision making, it is not known whether A2AR control glutamatergic synapse plasticity within the ...