Made available in DSpace on 2019-09-12T16:57:15Z (GMT). No. of bitstreams: 0 Previous issue date: 2009; Merck S.A Industrias Químicas; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Objective: To assess the pharmacokinetics of clarithromycin (CLR) and its effects oil oral and nasal microbiota in healthy volunteers in an open, randomized, two-period crossover design. Methods: A single 500 ...
Background Bipolar disorder (BD) patients have been reported to be associated higher creativity abilities, and recent data tend to support the hypothesis that dopaminergic system that could be associated with creativity. Catechol-O-methyltransferase (COMT) is one of the major enzymes involved in the metabolic degradation of dopamine. The COMT gene polymorphism (rs4680 or Val158Met) Met allele is reported to cau...
Background : Bipolar disorder is marked by alterations in coping skills which in turn impacts the disease course. Personality traits are associated with coping skills and for this reason it has been suggested that personality traits of patients with BD may have influence over their coping skills. Objective : To investigate possible associations between coping skills and personality in individuals with bipolar d...
Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T19:07:58Z No. of bitstreams: 1 S0047-20852007000100006.pdf: 128090 bytes, checksum: 01a6ca5900641442c9e66a999db48ff6 (MD5); Made available in DSpace on 2013-08-22T19:07:58Z (GMT). No. of bitstreams: 1 S0047-20852007000100006.pdf: 128090 bytes, checksum: 01a6ca5900641442c9e66a999db48ff6 (MD5) Previous issue date: 2007-01-01; Made availabl...
Aripiprazol é um antipsicótico atípico (AAt) frequentemente indicado para o tratamento agudo da mania, assim como para quadros mistos de transtorno bipolar (TB) tipo I e para o tratamento de manutenção do TB tipo I. A potencial ação antidepressiva dos AAts possibilita que medicamentos dessa classe aumentem as chances do aparecimento de mania em indivíduos suscetíveis. Com o objetivo de sumarizar evidência que p...
At least 5% (Moreno, 2004 e Angst et al., 2003) of the general population have presented mania or hypomania. Irritability and depressive symptoms during brief hyperactivity episodes and the heterogeneity of symptoms complicate the diagnosis. Neurological, metabolic, endocrine, inflammatory diseases, besides drugs intoxication and abstinence can cause a manic syndrome. Sometimes hypomania or mania are misdiagnos...