12 documents found, page 1 of 2
Ten Key Questions on the 2023 Bethesda “AUS” Category: Practical Guidance for S...
Canberk, Sule; Simplício , Mariana; Bongiovanni , Massimo; Rodrigues, Elisabete; Capela , JoãoThe 2023 Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) redefines Atypia of Undetermined Significance (AUS) by introducing subclassification into AUS with nuclear atypia and AUS-other. This change reflects growing evidence that the risk of malignancy is subtype-dependent. For endocrine surgeons, this means that cytology can no longer be interpreted in isolation: AUS subtypes must be integrated wit...
A One pathology multicentre Portuguese approach to thyroid tumours of dogs and ...
Gaspar, Tiago; Borges, Inês; Canberk, Sule; Monteiro, Alexandra; Catarino, José; Pinto, Mafalda; Teixeira, Elisabete; Canadas-Sousa, Ana; Branco, SandraThyroid tumours are the most common endocrine tumours of dogs and cats. Feline thyroid tumours are essentially functional adenomas curable with thyroidectomy, whereas most canine thyroid tumours are non-functional carcinomas either unresectable or recurrent within two years in up 50%. The oncobiology of these tumours remains unclear, but investigating this aspect could contribute to the development of targeted ...
Intraoperative Neuromonitorization In Thyroid Surgery – A Qualitative Leap? Um ...
Mourão, Mariana; Guerreiro, Sofia; Crespo, Ana; Canberk, Sule; Tavares, Paula; Coutinho, José; Marques, Hugo Pinto Introduction: Identifying and preserving the recurrent laryngeal nerve is essential in thyroid surgery. Nerve Intraoperative Monitoring aids with this task and helps predict post-operative prognosis. Case Description: A 64-year-old male undergoes a Total Thyroidectomy with central and left lymphadenectomy for papillary thyroid cancer with intra-operative neuro-monitoring. Discussion: One of the most dread...
Comparative Cyto-Histological Genetic Profile in a Series of Differentiated Thy...
Matos, Maria de Lurdes; Pinto, Mafalda; Alves, Marta; Canberk, Sule; Gonçalves, Ana; Bugalho, Maria João; Papoila, A.L.; Soares, PaulaFunding Information: This research received funding for SC, in the framework of a Ph.D. grant (SFRH/BD/147650/2019) supported by Portuguese funds through Fundação para a Ciência e a Tecnologia (FCT). This study is part of the project “Institute for Research and Innovation in Health Sciences” (UID/BIM/04293/2019) and the project “The Porto Comprehensive Cancer Center” ref. NORTE-01-0145-FEDER-072678—Consórcio PO...
Welcoming the New, Revisiting the Old: a Brief Glance at Cytopathology Reportin...
Luis, Rita; Thirunavukkarasu, Balamurugan; Jain, Deepali; Canberk, SuleThis review addresses new reporting systems for lung and pancreatobiliary cytopathology as well as the most recent edition of The Bethesda Reporting System for Thyroid Cytopathology. The review spans past, present, and future aspects within the context of the intricate interplay between traditional morphological assessments and cutting-edge molecular diagnostics. For lung and pancreas, the authors discuss the e...
Significance of Furin Expression in Thyroid Neoplastic Transformation
Azevedo, Maria Teresa; Macedo, Sofia; Canberk, Sule; Cardoso, Luís; Gaspar, Tiago Bordeira; Pestana, Ana; Batista, Rui; Sobrinho-Simões, ManuelAngiotensin-Converting Enzyme 2 (ACE2), Transmembrane Serine Protease 2 (TMPRSS2), and Furin were known to be key players in the SARS-CoV-2 infection, and the thyroid gland was revealed to be one of the relevant targets of the virus. Regardless of the viral infection, the expression of these molecules in the thyroid gland and their putative role in the neoplastic transformation of the thyrocytes has not been th...
DGCR8 microprocessor subunit mutation and expression deregulation in thyroid le...
Rodrigues, Lia; Canberk, Sule; Macedo, Sofia; Soares, Paula; Vinagre, JoãoDeregulation of microRNA (miRNA) processing is a driver event in several tumours including thyroid cancer. DiGeorge Critical Region 8 (DGCR8) gene holds a critical role in miRNA biogenesis, as a microprocessor complex component, and in the development of the thyroid. Previous studies identified a DGCR8 mutation – the variant c.1552G>A p.(E518K) – in cases of thyroid cancer and proposed to cause a familial syndr...
Generation of an obese diabetic mouse model upon conditional Atrx disruption
Gaspar, Tiago Bordeira; Jesus, Tito Teles; Azevedo, Maria Teresa; Macedo, Sofia; Soares, Mariana Alves; Martins, Rui Sousa; Leite, Rúben; Rodrigues, LiaATRX mutations occur in up to 17% of human pancreatic neuroendocrine tumours (PanNETs), and recent evidence points towards its inability to drive PanNET formation in mouse pancreas while predisposing individuals to inflammageing. Aiming to explore the additional non-tumourigenic consequences of Atrx deletion, we characterised an aged series of Atrx conditional disruption in β cells using the Pdx1 promoter. Homo...
Performance of the Bethesda system for reporting thyroid cytology in multi-inst...
Canberk, Sule; Barroca, Helena; Girão, Inês; Aydın, Ozlem; Uguz, Aysun; Erdogan, Kıvılcım; Tastekin, Ebru; Bongiovanni, Massimo; Soares, PaulaBackground: To evaluate the performance of TBSRTC through multi-institutional experience in the paediatric population and questioning the management recommendation of ATA Guidelines Task Force on Paediatric Thyroid Cancer; Methods: A retrospective search was conducted in 4 institutions to identify consecutive thyroid FNAC cases in paediatric population between 2000 and 2018. Following the 2nd TBSRTC, the risk o...
Comprehensive Assessment of TERT mRNA Expression across a Large Cohort of Benig...
Pestana, Ana; Batista, Rui; Celestino, Ricardo; Canberk, Sule; Sobrinho-Simões, Manuel; Soares, PaulaThe presence of TERT promoter (TERTp) mutations in thyroid cancer have been associated with worse prognosis features, whereas the extent and meaning of the expression and activation of TERT in thyroid tumours is still largely unknown. We analysed frozen samples from a series of benign and malignant thyroid tumours, displaying non-aggressive features and low mutational burden in order to evaluate the presence of...