3 documents found, page 1 of 1
How many biomarker measurements are needed to predict prognosis in Crohn's dise...
Magro, Fernando; Estevinho, Maria Manuela; Catalano, Gaia; Patita, Marta; Arroja, Bruno; Lago, Paula; Rosa, Isadora; Sousa, Helena TavaresBackgroundTimely stratification of Crohn's disease (CD) is essential for patients' management. The use of noninvasive accurate biomarkers is key to monitor treatment and to pursue mucosal healing, the ultimate treatment endpoint in CD. ObjectiveWe aimed to evaluate the performance of readily available biomarkers and develop risk matrices to predict CD progression. MethodsData from 289 CD patients receiving infl...
Acute necrosis of oesophagus.
Araújo, Ricardo; Castanheira, António; Machado, Joana; Ramalho, Ana; Cancela, Eugénia; Ministro, Paula; Silva, AméricoAcute esophageal necrosis is a very rare pathological entity, first described in 1990 by Goldenberg. The authors report the case of a patient of 79 years of age with this disease. The etiology of this type of esophageal injury is not yet well defined and has a reported mortality between 33 and 50% . We present this case by the rarity of the disease and the exuberance of endoscopic images in demonstration of thi...
Analysis of the UDP-glucuronosyltransferase gene in Portuguese patients with a ...
Costa, Elísio; Vieira, Emília; Martins, Marcia; Saraiva, Jorge A.; Cancela, Eugénia; Costa, Miguel Rocha; Bauerle, Roswitha; Freitas, Teresa R.We describe the molecular study in a cohort of 120 Portuguese patients with the clinical diagnosis of Gilbert syndrome and in one with the diagnosis of Crigler–Najjar syndrome type II, as well as a prenatal diagnosis of Crigler–Najjar syndrome type I. Among the 120 unrelated patients with Gilbert syndrome, 110 were homozygous for the [TA]7 allele ([TA]7/[TA]7), and one patient was a compound heterozygote for tw...