18 documents found, page 1 of 2
Untangling sex differences in glia-to-neuron communication in chronic alcohol e...
Pacheco, Raquel; Canedo, Teresa; Rodrigues, Ana Margarida; Moreira, Joana; Relvas, João B.; Vieira, Cristina P.; Socodato, Renato; Sumavielle, TeresaExcessive alcohol consumption is global health challenge with profound neurobiological consequences. Our laboratory has shown that alcohol exposure induces reactive astrocytic changes, affecting gene expression, activity, and proliferation, while also altering microglial morphology and immune responses [1]. This study aims to characterise sex-specific effects of chronic alcohol consumption on the prefrontal cor...
Deciphering neuroimmune interactions in alcohol intake in mouse model of interm...
Pacheco, Raquel; Canedo, Teresa; Rodrigues, Ana M.; Moreira, Joana; Relvas, João B.; Socodato, Renato; Summavielle, Teresa; Summavielle, TeresaExcessive alcohol consumption continues to pose a significant global health challenge, with detrimental effects on millions of individuals. Our laboratory has shown that alcohol exposure triggers reactive changes in astrocytes, including alterations in gene expression, activity, and proliferation, while also affecting microglial morphology and immune responses. We are to characterizing the effects of chronic al...
IL-10 and Cdc42 as critical modulators in methamphtamine-induced neuroinflammation
Silva, Ana Isabel; Socodato, Renato; Pinto, Carolina; Terceiro, Ana Filipa; Canedo, Teresa; Relvas, João Bettencourt; Saraiva, MargaridaPsychoactive substances, such as Methamphetamine (Meth), can induce complex neuroinflammatory responses that modulate the neuron-glia cross talk and strongly affect behavioral responses. Recently we have reported that Meth stimulates astrocytes to release tumor necrosis factor (TNF) and glutamate, leading to microglial activation, microgliosis and loss of risk-assessment. Here, we started by investigating the a...
Microglial RAC1 drives experience-dependent brain plasticity
Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C. S.; Moreira, Joana Tedim; Ferreira, João Galvão; Canedo, Teresa; Magalhães, AnaMicroglia, the immune defenders of the brain, continuously extend and retract their processes to sense and decipher their local environment. This includes interactions with synapses to maintain brain homeostasis. To do this, microglia rely on the actin cytoskeleton and subsequent intracellular signaling, which is adapted in response to external signals released by cells undergoing intense synaptic activity. Thu...
The role of RAC1 in methamphtamine-induced neuroinflammation
Terceiro, Ana Filipa; Canedo, Teresa; Silva, Ana Isabel; Magalhães, Ana; Relvas, João; Summavielle, Teresa; Summavielle, TeresaMethamphetamine (Meth), a powerful psychostimulant, induces detrimental neuroinflammatory responses, in the brain reward system that seem to contribute to maintenance of addictive behaviour. Yet, the mechanisms regulating these processes in microglial cells are not clear. We have previously shown that exposing WT mice to Meth (4x5 mg/kg, 2h intervals) induces microgliosis concomitant with decreased microglia ce...
IL-10 and Cdc42 modulate astrocyte-mediated microglia activation in methampheta...
Silva, Ana Isabel; Socodato, Renato; Pinto, Carolina; Terceiro, Ana Filipa; Canedo, Teresa; Relvas, João Bettencourt; Saraiva, MargaridaMethamphetamine (Meth) use is known to induce complex neuroinflammatory responses, particularly involving astrocytes and microglia. Building upon our previous research, which demonstrated that Meth stimulates astrocytes to release tumor necrosis factor (TNF) and glutamate, leading to microglial activation, this study investigates the role of the anti-inflammatory cytokine interleukin-10 (IL-10) in this process....
Methamphetamine activates rac1 in striatal microglia
Terceiro, Ana Filipa; Canedo, Teresa; Silva, Ana Isabel; Magalhães, Ana; Relvas, João; Summavielle, Teresa; Summavielle, TeresaMethamphetamine (Meth), a powerful psychostimulant, induces profound synaptic and morphological alterations alongside with detrimental neuroinflammatory responses, in the brain reward system. Yet, the mechanisms regulating these processes in microglial cells are not clear. We have previously shown that exposing WT mice to Meth (4x5mg/kg, 2h intervals) induces microgliosis concomitant with decreased microglia ce...
Microglial Rac1 is essential for experience-dependent brain plasticity and cogn...
Socodato, Renato; Almeida, Tiago O.; Portugal, Camila C.; Santos, Evelyn C.S.; Tedim-Moreira, Joana; Ferreira, João Galvão; Canedo, TeresaMicroglia, the largest population of brain immune cells, continuously interact with synapses to maintain brain homeostasis. In this study, we use conditional cell-specific gene targeting in mice with multi-omics approaches and demonstrate that the RhoGTPase Rac1 is an essential requirement for microglia to sense and interpret the brain microenvironment. This is crucial for microglia-synapse crosstalk that drive...
Deciphering the astrocytic and synaptic changes under chronic alcohol exposure ...
Rodrigues, Ana Margarida; Canedo, Teresa; Terceiro, Ana Filipa; Tedim-Moreira, Joana; Silva, Ana Isabel; Magalhães, Ana; Relvas, JoãoDrug abuse is characterized by a compulsive and persistent drug-seeking behaviour, despite the harmful emotional, physical and social consequences. Our laboratory has previously found that the neuronal-glial crosstalk is critical in relaying the changes caused by acute exposure to psychoactive drugs through neuroimmune mechanisms. We have also reported that microglia can engulf postsynaptic components in the pr...
Microglial Rac1 is essential for microglia-synapse crosstalk and cognitive perf...
Almeida, Tiago O.; Socodato, Renato; Portugal, Camila C.; Santos, Evelyn C. S.; Moreira, Joana Tedim; Ferreira, João Galvão; Canedo, TeresaMicroglia, the main immune defenders of the brain, rapidly detect and react to stimuli due to constant extension andretraction of their processes. When engaged by external cues, that can be either inflammatory or products resulting from synaptic activity, microglia dramatically change their morphology and initiate a response to reestablish brain homeostasis. Additionally, microglia can also regulate and sustain...