45 documents found, page 1 of 5
Risk of colonization with multidrug-resistant gram-negative bacteria among trav...
Pedro, Diogo; Santos, Daniela; Meneses, Maria; Gonçalves, Fátima; Jantarada Domingos, Gonçalo; Caneiras, CatiaGlobalization in the 21st century has posed several challenges. In particular, the spread of multidrug-resistant bacterial strains, especially Gram-negative bacteria, which are prevalent in certain regions of the world, is one of the most critical issues. This raises concerns about the risks associated with the booming tourism industry and migratory flows. In fact, even transient colonization with multidrug-res...
Unveiling the prevalence and antimicrobial resistance landscape of Pantoea genu...
Holy, Ondrej; Sladecek, Vladimir; Bzdil, Jaroslav; Zouharova, Monika; Parra-Flores, Julio; Caneiras, CatiaThe genus Pantoea, of which Pantoea agglomerans is the most common species, is an emerging Gram-negative facultative anaerobic bacillus that causes a wide range of opportunistic infections. To date, the prevalence, antibiotic resistance, and pathogenic potential of this bacterium in animals remains largely unexplored. The aim of this work was to describe the prevalence of microorganisms of the genus Pantoea in ...
Extensively drug-resistant Pseudomonas aeruginosa: clinical features and treatm...
Pedro, Diogo; Paulo, Sérgio; Mimoso Santos, Carla; Fonseca, Ana Bruschy; Cristino, José Melo; Ayres Pereira, Álvaro; Caneiras, CatiaIntroduction: Extensively drug-resistant Pseudomonas aeruginosa (XDR-PA) is a growing concern due to its increasing incidence, limited therapeutic options, limited data on the optimal treatment, and high mortality rates. The study aimed to characterize the population, the outcome and the microbiological characteristics of XDR-PA identified in a Portuguese university hospital center. Methods: All XDR-PA isolates...
In the flow of molecular miniaturized fungal diagnosis
Zolotareva, Maria; Cascalheira, Francisco; Caneiras, Catia; Bárbara, Cristina; Caetano, Diogo Miguel; Teixeira, Miguel CachoThe diagnosis of fungal infections presents several challenges and limitations, stemming from the similarities in symptomatology, diversity of underlying pathogenic species, complexity of fungal biology, and scarcity of rapid, affordable, and point-of-care approaches. In this review, we assess technological advances enabling the conversion of cutting-edge laboratory molecular diagnostic methods to cost-effectiv...
Digital health and patient adherence: a qualitative study in older adults
Ferreira-Brito, Filipa; Alves, Sérgio; Guerreiro, Tiago; Santos, Osvaldo; Caneiras, Catia; Carriço, Luis; Verdelho, AnaIntroduction: Computer confidence and computer self-efficacy can impact an individual's perceived ease of use and usefulness of technology, ultimately determining adherence to digital healthcare services. However, few studies focus on assessing the impact of non-clinical factors on the efficacy and adherence to digital healthcare platforms. Objective: We aimed to analyse the role of non-clinical factors (i.e. c...
Effectiveness and use of home high flow nasal cannula in Portugal: Where are we?
Jácome, Cristina; Duarte, Mónica; Winck, João Carlos; Díaz Lobato, Salvador; Caneiras, CatiaOver the past two decades, high flow nasal cannula (HFNC) has emerged as a home treatment for patients with chronic respiratory diseases and chronic respiratory failure. This therapy provides heated and humidified gas admixture at a high flow rate (up to 60 L/min) via a wide-bore nasal cannula and its key benefits include its ability to deliver precise oxygen concentrations and reduce work of breathing.1 It ser...
Measurement properties of the incremental step test for people with chronic obs...
Gonçalves, Tânia; Carlos Winck, João; Silva, Fátima; Caneiras, Catia; Montes, António Mesquita; Vilarinho, RuiObjectives: The new incremental step test (IST) is a field test that was developed for people with chronic obstructive pulmonary disease (COPD), based on the characteristics of the incremental shuttle walk test (ISWT); however, its measurement properties still need to be determined. We aimed, first, to assess the construct validity (through the comparison with the ISWT), within-day reliability and measurement e...
Virulence factors in carbapenem-resistant hypervirulent Klebsiella pneumoniae
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Duarte, Aida; Caneiras, CatiaHypervirulence and carbapenem-resistant have emerged as two distinct evolutionary pathotypes of Klebsiella pneumoniae, with both reaching their epidemic success and posing a great threat to public health. However, as the boundaries separating these two pathotypes fade, we assist a worrisome convergence in certain high-risk clones, causing hospital outbreaks and challenging every therapeutic option available. To...
Saúde ambiental : caderno de notas soltas III
Santos, Ricardo; Santos, Osvaldo; Abreu, Ana; Caminha, Luís; Costa, Andreia; Sul, Susana; Nogueira, Paulo Jorge; Henriques, Adriana; Arriaga, MiguelNa sua 3.ª edição, o Caderno de Notas Soltas pretende reunir diferentes perspetivas e metodologias, celebrando a sua razão de ser e a nobreza da sua génese intimamente ligada à realidade dos estudantes. Na verdade, passados três anos retomamos uma colaboração firmada desde a primeira hora com a Associação de Estudantes da Faculdade de Medicina de Lisboa (AEFML), num registo de proximidade da comunidade estudant...
Genomic characterisation of a novel KPC-98-producing clinical Klebsiella pneumo...
Mendes, Gabriel; Santos, Maria Leonor; Ramalho, João Francisco; Bruschy-Fonseca, Ana; Lito, Luís; Pedro, Diogo; Duarte, Aida; Cristino, José MeloCeftazidime/avibactam (CZA) is a novel drug that inactivates Ambler class A, including Klebsiella pneumoniae carbapenemases (KPC), class C and class D β-lactamases, but is not active against metallo-β-lactamases (class B). Despite its limited use worldwide, emerging cases of CZA-resistant isolates producing variants of the blaKPC gene have been reported. In this study, we report a novel KPC-98 variant conferrin...